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Silence Therapeutics plc (SLN) Create: Alert

All | News | Filings
Date FiledTypeDescription
08/16/2023 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS You should read the following discussion and analysis of financial condition and operating results together with our unaudited financial statements as of and for the three and six months ended June 30, 2023 and the related notes to those unaudited condensed consolidated financial statements included as Exhibit 99.1 to this Report on Form 6-K, as well as our audited consolidated financial statements and related notes as disclosed in our Annual Report on Form 20-F for the year ended December 31, 2022 filed with the Securities and Exchange Commission on March 15, 2023. The statements in this discussion with respect to our plans and strategy for our business, including expectations regarding our future liquid..."
07/11/2023 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Inquiries: Silence Therapeutics plc Gem Hopkins, Head of IR and Corporate Communications [email protected] Tel: +1 637-3208 About Silence Therapeutics Silence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet need. Silence's proprietary mRNAi GOLD™ platform can be used to create siRNAs that precisely target and silence disease-associated genes in the liver, which represents a substantial opportunity. Silence's wholly owned product candidates include zerlasiran designed to address the high and prevalent unmet medical need in reducing cardiovascular risk in people born with high ..."
07/03/2023 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K"
05/04/2023 6-K Quarterly results
05/01/2023 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Inquiries: Silence Therapeutics plc Gem Hopkins, Head of IR and Corporate Communications [email protected] Tel: +1 637-3208 About Silence Therapeutics Silence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet need. Silence's proprietary mRNAi GOLD™ platform can be used to create siRNAs that precisely target and silence disease-associated genes in the liver, which represents a substantial opportunity. Silence's wholly owned product candidates include SLN360 designed to address the high and prevalent unmet medical need in reducing cardiovascular risk in people born with high leve..."
04/27/2023 6-K Quarterly results
03/28/2023 6-K Quarterly results
01/12/2023 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Therapeutics Provides SLN360 and SLN124 Clinical Program Updates 12 January 2023 LONDON, Silence Therapeutics plc, Nasdaq: SLN , an experienced and innovative biotechnology company committed to transforming people’s lives by silencing diseases through precision engineered medicines, today provided the following SLN360 and SLN124 program updates during a presentation at the 41st Annual J.P. Morgan Healthcare Conference: SLN360 for cardiovascular disease • The first subjects have been dosed in the SLN360 phase 2 study in high-risk atherosclerotic cardiovascular disease . The Company plans to complete enrollment in the study in the fourth quarter of 2023. More information on the trial can be found here. • Silence expects data from the ongoing phase 1 multiple dose study ..."
11/07/2022 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Assessment showed participants who received a single dose of SLN360 maintained median reductions over 80% over a five-month period 5 November 2022 Silence Therapeutics plc, Nasdaq: SLN , an experienced and innovative biotechnology company committed to transforming people’s lives by silencing diseases through precision engineered medicines, today presented data from an analysis of its APOLLO phase 1 single dose study of SLN360, an investigational short interfering ribonucleic acid , in healthy adults with high lipoprotein ”), a key genetic risk factor for heart disease, at the American Heart Association 2022 Annual Meeting. The moderated poster entitled, “Time Averaged Lipoprotein Reduction with SLN360, A Novel SiRNA Targeting Lp in Healthy Adults with Elevated Lp,” assessed Lp levels of pa..."
09/29/2022 6-K Quarterly results
08/16/2022 6-K Quarterly results
08/12/2022 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Therapeutics Announces Pricing of Underwritten Offering LONDON, August 11, 2022 - Silence Therapeutics plc , a leader in the discovery, development and delivery of novel short interfering ribonucleic acid therapeutics for the treatment of diseases with significant unmet medical need, today announced the pricing of an underwritten offering of 5,950,000 American Depositary Shares , each representing three ordinary shares, at a price of $9.50 per ADS, for aggregate gross proceeds of approximately $56.5 million, before deducting underwriting discounts and commissions and other offering expenses. All of the ADSs are being offered by Silence. The offering is expected to close on or about August 16, 2022, subject to customary closing conditions. Silence intends to use the net proceeds of ..."
08/11/2022 6-K Quarterly results
06/14/2022 6-K Quarterly results
05/16/2022 6-K Quarterly results
05/16/2022 6-K Quarterly results
04/25/2022 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Therapeutics Achieves $2 Million Research Milestone in Hansoh Pharma Collaboration"
04/04/2022 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"SLN360 reduced Lp – a key genetic risk factor for heart disease - by up to 98% with reductions of up to 81% persisting at 150 days – Results were simultaneously published in The Journal of the American Medical Association 3 April 2022 Silence Therapeutics plc, Nasdaq: SLN , a leader in the discovery, development and delivery of novel short interfering ribonucleic acid therapeutics for the treatment of diseases with significant unmet medical need, today presented detailed results from its phase 1 APOLLO trial that showed SLN360, an investigational siRNA, reduced levels of lipoprotein ”), an important genetic risk factor for heart disease, by up to 98% in healthy adults with high Lp. Findings from the “APOLLO Trial: Magnitude and Duration of Effects of a Short-interfering RNA Targeting Lipop..."
03/23/2022 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Therapeutics and Mallinckrodt Announce Submission of Clinical Trial Application for SLN501 Silence to receive $3 million research milestone payment from Mallinckrodt Phase 1study expected to begin in the first half of 2022"
02/22/2022 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Therapeutics Appoints Craig Tooman President and Chief Executive Officer Mark Rothera steps down as President and CEO"
02/09/2022 6-K Quarterly results
12/13/2021 6-K Quarterly results
11/26/2021 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "Regulatory News Announcement",
"Regulatory News Announcement"
11/16/2021 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "Report for the Three and Nine Months Ended September 30, 2021",
"Report for the Three and Nine Months Ended September 30, 2021"
11/01/2021 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "Regulatory News Announcement",
"Regulatory News Announcement"
10/21/2021 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Therapeutics Provides mRNAi GOLD™ Platform and Pipeline Updates at 2021 R&D Day -"
10/15/2021 6-K Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]:
Docs: "6-K",
"Silence Announces Proposed Cancellation of Admission of its Ordinary Shares to Trading on AIM and Transition of its Primary Trading Venue to the Nasdaq Global Market Notice of General Meeting to be held on 1 November 2021",
"Mark Rothera, President and Chief Executive Officer of Silence Therapeutics, said: “We believe Hansoh's extensive clinical development and commercialization experience in China make them an ideal partner. This collaboration is a good example of our hybrid model in action, balancing proprietary and partnered programs to maximize the substantial opportunity of our mRNAi GOLD ™ platform for targeting disease associated genes in the liver. The Hansoh partnership enables us to move two new proprietary programs forward subsidized by non-dilutive capital while also gaining access to the second largest pharmaceutical market globally. We look forward to discussing this deal and our broader pipeline in more detail at our upcoming R&D Day on October 21st in New York City.” Eliza Sun, Executive Direct...",
"Regulatory News Announcement",
"Information Circular",
"Frequently Asked Questions"
08/12/2021 6-K Quarterly results
08/12/2021 6-K Quarterly results
06/15/2021 6-K Quarterly results
06/07/2021 6-K Quarterly results
05/25/2021 6-K Quarterly results
05/19/2021 6-K Quarterly results
05/07/2021 6-K Quarterly results
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