| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-05-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 8-K | 10-K | 10-K | 10-K | 8-K | 10-K | 10-K | 10-K |
| Revenues: |
| Net product sales | | 9.6 | | | | | | |
| Other | | 4.1 | | | | | | |
| Total revenues [+] | 81.7 | 13.6 | 3.6 | 0.0 | 100.9 | 9.8 | 28.9 | 27.2 |
| Royalties | 142.7 | | | | 100.9 | | | |
| Products | | 9.6 | | | | | | |
| Services | | | | | | | | 2.8 |
| Contracts | | | | | | | | 24.4 |
| Revenue growth [+] | 498.8% | 274.0% | | -100.0% | | -66.0% | 6.1% | -6.1% |
| Service and other product revenue | | | | | | | | -24.3% |
| Cost of goods sold | 149.4 | 0.5 | 5.6 | 1.3 | 203.2 | 10.7 | 0.0 | 0.0 |
| Gross profit | -67.7 | 13.1 | -2.0 | -1.3 | -102.2 | -0.9 | 28.9 | 27.2 |
| Gross margin | -82.9% | 96.0% | -53.5% | | -101.3% | -9.2% | 100.0% | 100.0% |
| Selling, general and administrative | 148.5 | 99.6 | 60.8 | 39.0 | 39.0 | 25.9 | 27.0 | 26.3 |
| Research and development | | 138.0 | 115.6 | 100.9 | | 67.4 | 41.8 | 27.9 |
| Other operating expenses | -1.9 | | -5.6 | -1.3 | -1.3 | | 22.5 | 22.7 |
| EBITDA [+] | -214.3 | -223.0 | -171.5 | -139.7 | | -93.8 | -61.1 | -48.1 |
| EBITDA growth | -3.9% | 30.0% | 22.8% | 48.9% | | 53.7% | 26.9% | 33.0% |
| EBITDA margin | -262.4% | -1634.2% | -4701.6% | | -138.6% | -955.3% | -211.6% | -177.0% |
| Depreciation and amortization | | 1.5 | 1.3 | 0.2 | | 0.4 | 1.4 | 1.6 |
| EBITA | -214.3 | -224.5 | -172.8 | -139.9 | -139.9 | -94.2 | -62.5 | -49.7 |
| EBITA margin | -262.4% | -1645.3% | -4736.4% | | -138.6% | -959.6% | -216.5% | -182.9% |
| Amortization of intangibles | 7.9 | 3.9 | | | | | | |
| EBIT [+] | -222.2 | -228.4 | -172.8 | -139.9 | -139.9 | -94.2 | -62.5 | -49.7 |
| EBIT growth | -2.7% | 32.2% | 23.5% | 48.4% | | 50.9% | 25.6% | 31.6% |
| EBIT margin | -272.0% | -1674.2% | -4736.4% | | -138.6% | -959.6% | -216.5% | -182.9% |
| Non-recurring items [+] | 1.9 | 19.3 | 257.0 | 1.3 | 1.3 | 25.7 | 10.2 | -2.0 |
| Asset impairment | | | | | | 1.1 | 8.4 | |
| Unusual expense | 1.9 | | | | 1.3 | | | |
| Business exit costs | | | | | | 0.5 | | |
| Loss on contingent liability | | 8.6 | 5.6 | 1.3 | | 24.1 | 1.8 | -2.0 |
| In-process research & development | | 10.7 | 251.4 | | | | | |
| Interest expense | 15.3 | 3.8 | 0.0 | 0.0 | | 2.6 | 2.8 | 3.1 |
| Interest expense | 15.3 | 3.8 | 0.0 | 0.0 | | 2.6 | 2.8 | 3.1 |
| Other income (expense), net [+] | 12.1 | 24.7 | 10.3 | 17.5 | 17.5 | -3.4 | 5.9 | -6.8 |
| Gain (loss) on debt retirement | | | | | | -4.9 | | |
| Other | -11.4 | 21.8 | 0.5 | 10.3 | 10.3 | 0.0 | 0.0 | -0.1 |
| Pre-tax income | -227.3 | -226.8 | -419.5 | -123.7 | -123.7 | -126.0 | -69.6 | -57.6 |
| Income taxes | 0.1 | -17.4 | 0.0 | 0.0 | 0.2 | 0.0 | -0.9 | -15.9 |
| Tax rate | | 7.7% | 0.0% | 0.0% | | 0.0% | 1.4% | 27.6% |
| Net income | -227.4 | -209.4 | -419.5 | -123.7 | -123.9 | -126.0 | -68.7 | -41.7 |
| Net margin | -278.4% | -1534.7% | -11499.5% | | -122.8% | -1283.2% | -238.1% | -153.4% |
| |
| Basic EPS [+] | ($4.07) | ($3.90) | ($9.74) | ($3.27) | ($3.26) | ($4.62) | ($2.77) | ($1.94) |
| Growth | 4.4% | -60.0% | 198.2% | -29.3% | | 66.6% | 42.5% | -156.4% |
| Diluted EPS [+] | ($4.07) | ($3.90) | ($9.74) | ($3.27) | ($3.26) | ($4.62) | ($2.77) | ($1.94) |
| Growth | 4.4% | -60.0% | 198.2% | -29.3% | | 66.6% | 42.5% | -156.5% |
| |
| Shares outstanding (basic) [+] | 55.9 | 53.7 | 43.1 | 37.9 | 37.9 | 27.3 | 24.8 | 21.4 |
| Growth | 4.0% | 24.7% | 13.7% | 38.8% | | 10.2% | 15.6% | 20.3% |
| Shares outstanding (diluted) [+] | 55.9 | 53.7 | 43.1 | 37.9 | 37.9 | 27.3 | 24.8 | 21.4 |
| Growth | 4.0% | 24.7% | 13.7% | 38.8% | | 10.2% | 15.6% | 20.1% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |