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| In millions, except per share items | Dec-31-12 | Dec-31-11 | Dec-31-10 | Dec-31-09 | Dec-31-08 | Dec-31-07 | Dec-31-06 | Dec-31-05 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Product revenue | 64.0 | | | | | | | |
| Royalty revenue | 8.3 | | | | | | | |
| Contract revenue from collaborations | 1.5 | 160.2 | | 1.0 | | | | |
| License revenue | | | 59.2 | | | | | |
| Other | 288.4 | 287.0 | 265.4 | 250.4 | | | | |
| Total revenues [+] | 362.2 | 447.2 | 324.5 | 251.4 | 194.3 | 90.4 | 29.5 | 63.1 |
| Licensing | | | 59.2 | | | | | |
| Products | 64.0 | | | | | | | |
| Services | 1.5 | 160.2 | | 1.0 | | | | |
| Revenue growth [+] | -19.0% | 37.8% | 29.1% | 29.4% | 114.9% | 206.3% | -53.2% | 76.1% |
| Contract revenue from collaborations | -99.1% | | | | | | | |
| Cost of goods sold | 1.3 | -442.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 62.1 |
| Gross profit | 360.8 | 889.5 | 324.5 | 251.4 | 194.3 | 90.4 | 29.5 | 1.0 |
| Gross margin | 99.6% | 198.9% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 1.6% |
| Selling, general and administrative | 224.2 | 168.0 | 114.2 | 101.1 | 81.0 | 60.5 | 50.0 | 39.7 |
| Research and development | 325.3 | 268.1 | 185.7 | 128.5 | 123.7 | | | |
| Other operating expenses | 78.5 | 348.9 | 92.9 | 1.5 | | 83.3 | 84.2 | 63.1 |
| EBITDA [+] | -252.6 | 110.1 | -64.7 | 21.8 | -9.1 | -52.4 | -103.9 | -101.2 |
| EBITDA growth | -329.4% | -270.2% | -396.0% | -341.0% | -82.7% | -49.6% | 2.7% | 104.5% |
| EBITDA margin | -69.7% | 24.6% | -19.9% | 8.7% | -4.7% | -57.9% | -351.9% | -160.3% |
| Depreciation | 5.2 | 5.5 | 3.6 | 1.6 | 1.3 | 1.0 | 0.8 | 0.6 |
| EBITA | -257.8 | 104.6 | -68.3 | 20.2 | -10.4 | -53.4 | -104.7 | -101.8 |
| EBITA margin | -71.2% | 23.4% | -21.1% | 8.0% | -5.4% | -59.1% | -354.5% | -161.3% |
| Amortization of intangibles | 9.3 | | | | | | | |
| EBIT [+] | -267.1 | 104.6 | -68.3 | 20.2 | -10.4 | -53.4 | -104.7 | -101.8 |
| EBIT growth | -355.3% | -253.1% | -437.8% | -294.5% | -80.5% | -49.0% | 2.8% | 105.0% |
| EBIT margin | -73.7% | 23.4% | -21.1% | 8.0% | -5.4% | -59.1% | -354.5% | -161.3% |
| Non-recurring items [+] | | 6.3 | | | | | | |
| Restructuring charges | | 6.3 | | | | | | |
| Interest expense, net [+] | 19.1 | 17.8 | 16.6 | 2.8 | -12.7 | | | -6.2 |
| Interest expense | 21.8 | 20.2 | 19.4 | 6.9 | | | | |
| Interest income | 2.7 | 2.4 | 2.8 | 4.0 | 12.7 | | | 6.2 |
| Other income (expense), net | 1.6 | -4.1 | -0.8 | | | 19.3 | 12.0 | 0.4 |
| Pre-tax income | -284.6 | 76.4 | -85.7 | 17.4 | 2.3 | -34.2 | -92.7 | -95.2 |
| Income taxes | -96.8 | 0.3 | -0.8 | 1.2 | 0.3 | 0.0 | 0.0 | 0.0 |
| Tax rate | 34.0% | 0.4% | 1.0% | 7.1% | 15.1% | 0.0% | 0.0% | 0.0% |
| Net income | -187.8 | 76.1 | -84.8 | 16.2 | 1.9 | -34.2 | -92.7 | -95.2 |
| Net margin | -51.9% | 17.0% | -26.1% | 6.4% | 1.0% | -37.8% | -313.9% | -150.8% |
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| Basic EPS [+] | ($2.88) | $1.20 | ($1.35) | $0.27 | $0.03 | ($0.67) | ($2.20) | ($2.64) |
| Growth | -340.2% | -188.6% | -596.5% | 683.4% | -105.2% | -69.6% | -16.8% | 94.0% |
| Diluted EPS [+] | ($2.88) | $1.19 | ($1.35) | $0.27 | $0.03 | ($0.67) | ($2.20) | ($2.64) |
| Growth | -342.4% | -187.8% | -598.9% | 691.4% | -105.1% | -69.6% | -16.8% | 94.0% |
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| Shares outstanding (basic) [+] | 65.1 | 63.4 | 62.6 | 59.2 | 55.9 | 51.2 | 42.2 | 36.0 |
| Growth | 2.7% | 1.3% | 5.7% | 5.9% | 9.3% | 21.4% | 17.0% | 4.9% |
| Shares outstanding (diluted) [+] | 65.1 | 64.0 | 62.6 | 59.5 | 56.8 | 51.2 | 42.2 | 36.0 |
| Growth | 1.8% | 2.2% | 5.2% | 4.8% | 10.9% | 21.4% | 17.0% | 4.9% |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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