| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/10/2023 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 15k | $1.36 | $20.4k | | 08/10/2023 |
| 06/01/2023 | EXELIXIS, INC. | EXEL | Grant | | 20.7k | $0.00 | $0 | | 06/01/2023 |
| 06/15/2022 | BIOGEN INC. | BIIB | Grant | Common Stock | 2.3k | $0.00 | $0 | | 06/15/2022 |
| 06/09/2022 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 90k | $0.27 | $24.3k | | 06/09/2022 |
| 05/26/2022 | EXELIXIS, INC. | EXEL | Grant | | 19.6k | $0.00 | $0 | | 05/26/2022 |
| 02/22/2022 | EXELIXIS, INC. | EXEL | Sale | Common Stock | 84.5k | $19.56 | $1.7M | | 02/22/2022 |
| 11/30/2021 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock | 2.2M | $0.36 | $800k | | 11/30/2021 |
| 07/01/2021 | BIOGEN INC. | BIIB | Grant | Common Stock | 1.3k | $0.00 | $0 | | 07/01/2021 |
| 06/14/2021 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.5k | | 06/14/2021 |
| 05/27/2021 | EXELIXIS, INC. | EXEL | Grant | | 16.4k | $0.00 | $0 | | 05/27/2021 |
| 12/04/2020 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock | 793.5k | $0.63 | $500k | | 12/04/2020 |
| 12/04/2020 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock Purchase Warrant (Right to Buy) | 595.1k | $0.75 | $444.2k | | 12/04/2020 |
| 12/04/2020 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock | 793.5k | $0.63 | $500k | | 12/04/2020 |
| 11/24/2020 | Eucrates Biomedical Acquisition Corp. | | Other (disposition) | Ordinary Shares | 255.1k | $0.00 | $0 | See Footnote | 11/24/2020 |
| 06/17/2020 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 23.2k | $0.88 | $20.5k | | 06/17/2020 |
| 06/03/2020 | BIOGEN INC. | BIIB | Grant | Common Stock | 1.5k | $0.00 | $0 | | 06/03/2020 |
| 05/21/2020 | EXELIXIS, INC. | EXEL | Grant | | 15.5k | $0.00 | $0 | | 05/21/2020 |
| 05/13/2020 | EXELIXIS, INC. | EXEL | Exercise | Option (right to buy) | 120.8k | $5.82 | $703k | | 05/13/2020 |
| 05/08/2020 | EXELIXIS, INC. | EXEL | Exercise | Option (right to buy) | 30k | $4.58 | $137.4k | | 05/08/2020 |
| 05/08/2020 | EXELIXIS, INC. | EXEL | Exercise | Option (right to buy) | 15k | $5.92 | $88.8k | | 05/08/2020 |
| 05/08/2020 | EXELIXIS, INC. | EXEL | Sale | Common Stock | 45k | $25.84 | $1.2M | | 05/08/2020 |
| 02/03/2020 | Regulus Therapeutics Inc. | RGLS | Conversion | Class A-2 Convertible Preferred Stock | 84.6k | $0.00 | $0 | | 02/03/2020 |
| 02/03/2020 | Regulus Therapeutics Inc. | RGLS | Conversion | Common Stock | 846.3k | $0.00 | $0 | | 02/03/2020 |
| 12/24/2019 | Regulus Therapeutics Inc. | RGLS | Grant | Class A-2 Convertible Preferred Stock | 84.6k | $6.66 | $563.6k | | 12/24/2019 |
| 12/24/2019 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock Purchase Warrant (Right to Buy) | 846.3k | $0.67 | $563.6k | | 12/24/2019 |
| 10/10/2019 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 46.5k | $0.64 | $29.8k | | 10/10/2019 |
| 06/19/2019 | BIOGEN INC. | BIIB | Grant | Common Stock | 1.9k | $0.00 | $0 | | 06/19/2019 |
| 05/23/2019 | EXELIXIS, INC. | EXEL | Grant | | 10.3k | $0.00 | $0 | | 05/23/2019 |
| 05/23/2019 | EXELIXIS, INC. | EXEL | Grant | Option (right to buy) | 20.6k | $19.77 | $407.9k | | 05/23/2019 |
| 05/07/2019 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock | 370.4k | $1.08 | $400k | | 05/07/2019 |
| 05/07/2019 | Regulus Therapeutics Inc. | RGLS | Grant | Common Stock Purchase Warrant (Right to Buy) | 370.4k | $1.08 | $400k | | 05/07/2019 |
| 05/07/2019 | Regulus Therapeutics Inc. | RGLS | Purchase | Common Stock Purchase Warrant (Right to Buy) | 370.4k | $1.08 | $400k | | 05/07/2019 |
| 05/07/2019 | Regulus Therapeutics Inc. | RGLS | Purchase | Common Stock | 370.4k | $1.08 | $400k | | 05/07/2019 |
| 02/21/2019 | EXELIXIS, INC. | EXEL | Sale | Common Stock | 26.2k | $21.25 | $557.8k | | 02/21/2019 |
| 02/21/2019 | EXELIXIS, INC. | EXEL | Exercise | Option (right to buy) | 11.2k | $4.16 | $46.8k | | 02/21/2019 |
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