Spigelman Melvin K [Rocket]

Date	Name	Symbol	Type	Security	Shares	Price	Value	Reported
06/07/2023	AN2 Therapeutics, Inc.		Grant	Stock Option (right to buy)	23.7k	$5.91	$140.3k	06/07/2023
05/12/2022	AN2 Therapeutics, Inc.		Grant	Stock Option (right to buy)	10.4k	$17.28	$179.1k	05/12/2022
08/15/2018	SYNERGY PHARMACEUTICALS, INC.	SGYP	Exercise	Stock Options	150k	$1.20	$180k	08/15/2018
08/15/2018	SYNERGY PHARMACEUTICALS, INC.	SGYP	Payment of Exercise	Common Stock	101.7k	$0.00	$0	08/15/2018
06/16/2018	SYNERGY PHARMACEUTICALS, INC.	SGYP	Grant	Stock Options	114.8k	$1.80	$206.6k	06/16/2018
05/25/2018	MEDICINES CO /DE	MDCO	Sale	Common Stock	7.5k	$32.20	$241.5k	05/25/2018
05/25/2018	MEDICINES CO /DE	MDCO	Exercise	Stock Option (right-to-buy)	7.5k	$18.30	$137.2k	05/25/2018
06/28/2017	SYNERGY PHARMACEUTICALS, INC.	SGYP	Grant	Stock Options	12k	$1.40	$16.8k	06/28/2017
06/28/2017	SYNERGY PHARMACEUTICALS, INC.	SGYP	Disposition	Stock Options	12k	$1.40	$16.8k	06/28/2017
06/28/2017	SYNERGY PHARMACEUTICALS, INC.	SGYP	Grant	Stock Options	62.5k	$4.50	$281.2k	06/28/2017
05/24/2016	MEDICINES CO /DE	MDCO	Sale	Common Stock	15k	$37.00	$555k	05/24/2016
05/24/2016	MEDICINES CO /DE	MDCO	Exercise	Stock Option (right-to-buy)	15k	$18.60	$279k	05/24/2016
05/22/2012	MEDICINES CO /DE	MDCO	Grant	Common Stock	5.1k	$0.00	$0	05/22/2012
05/22/2012	MEDICINES CO /DE	MDCO	Grant	Option (right to buy)	12k	$21.14	$254.5k	05/22/2012
05/26/2011	MEDICINES CO /DE	MDCO	Grant	Common Stock	5.9k	$0.00	$0	05/26/2011
05/26/2011	MEDICINES CO /DE	MDCO	Grant	Option (right to buy)	13.3k	$18.18	$241k	05/26/2011