| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/29/2023 | PROKIDNEY CORP. | | Grant | Director stock option (right to buy) | 48.1k | $10.56 | $508.2k | | 06/29/2023 |
| 06/06/2023 | Beam Therapeutics Inc. | BEAM | Grant | Stock Option (Right to Buy) | 16.5k | $34.33 | $567.5k | | 06/06/2023 |
| 09/01/2022 | Beam Therapeutics Inc. | BEAM | Grant | Stock Option (Right to Buy) | 10.4k | $55.58 | $577.5k | | 09/01/2022 |
| 06/21/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock unit | 5k | $0.00 | $0 | | 06/21/2022 |
| 06/21/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock options (right to buy) | 29.3k | $18.09 | $530.2k | | 06/21/2022 |
| 05/20/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock unit | 1.6k | $0.00 | $0 | | 05/20/2022 |
| 01/18/2022 | Kymera Therapeutics, Inc. | | Grant | Stock Option (Right to Buy) | 24k | $39.61 | $950.6k | | 01/18/2022 |
| 12/22/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 6.3k | $189.13 | $1.2M | | 12/21/2021 |
| 12/22/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 2 | $190.50 | $381 | | 12/21/2021 |
| 12/22/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 319 | $186.02 | $59.3k | | 12/21/2021 |
| 12/21/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 14.2k | $0.00 | $0 | | 12/21/2021 |
| 12/10/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 2.4k | $42.22 | $100k | | 12/10/2021 |
| 12/10/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 1.1k | $88.95 | $100k | | 12/10/2021 |
| 12/10/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 1k | $96.45 | $99.9k | | 12/10/2021 |
| 12/10/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 839 | $119.13 | $100k | | 12/10/2021 |
| 11/12/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 10.4k | $170.36 | $1.8M | | 11/12/2021 |
| 11/12/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 7.7k | $171.35 | $1.3M | | 11/12/2021 |
| 11/12/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 14.5k | $172.22 | $2.5M | | 11/12/2021 |
| 11/12/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 683 | $173.25 | $118.3k | | 11/12/2021 |
| 11/12/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 670 | $174.34 | $116.8k | | 11/12/2021 |
| 11/12/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 34k | $7.10 | $241.2k | | 11/12/2021 |
| 11/05/2021 | Beam Therapeutics Inc. | BEAM | Grant | Stock Option (Right to Buy) | 13.1k | $89.53 | $1.2M | | 11/05/2021 |
| 05/28/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 1.7k | $0.00 | $0 | | 05/28/2021 |
| 05/20/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock unit | 1.6k | $0.00 | $0 | | 05/20/2021 |
| 05/20/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock options (right to buy) | 8.9k | $56.76 | $504.5k | | 05/20/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 3k | $128.30 | $386.8k | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 4.5k | $129.32 | $583.5k | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 9.1k | $130.34 | $1.2M | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 11.2k | $131.18 | $1.5M | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 3.5k | $132.32 | $460.6k | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.6k | $133.56 | $216.9k | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1k | $134.37 | $137.5k | | 05/13/2021 |
| 05/13/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 34k | $7.10 | $241.3k | | 05/13/2021 |
| 02/25/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 431 | $153.33 | $66.1k | | 02/24/2021 |
| 02/25/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 599 | $154.59 | $92.6k | | 02/24/2021 |
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