| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/19/2023 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 225k | $8.68 | $2M | | 05/19/2023 |
| 05/19/2023 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Series A Convertible Preferred Stock | 351k | $0.00 | $0 | | 05/19/2023 |
| 01/20/2022 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 430k | $1.21 | $520.3k | | 01/03/2022 |
| 01/03/2022 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 53k | $1.78 | $94.3k | | 01/03/2022 |
| 06/03/2021 | Cyclerion Therapeutics, Inc. | CYCN | Purchase | Common Stock | 823.2k | $3.28 | $2.7M | | 06/03/2021 |
| 05/06/2021 | Cyclerion Therapeutics, Inc. | CYCN | Purchase | Common Stock | 302k | $2.43 | $733.9k | | 05/06/2021 |
| 05/05/2021 | Cyclerion Therapeutics, Inc. | CYCN | Purchase | Common Stock | 398k | $2.53 | $1M | | 05/04/2021 |
| 05/04/2021 | Cyclerion Therapeutics, Inc. | CYCN | Purchase | Common Stock | 300k | $2.29 | $687k | | 05/04/2021 |
| 03/31/2020 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 153.8k | $2.65 | $407.7k | | 03/31/2020 |
| 11/22/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 75k | $2.01 | $150.8k | | 11/22/2019 |
| 07/10/2019 | Cyclerion Therapeutics, Inc. | CYCN | Exercise | Employee Stock Option (Right to Buy) | 2k | $6.04 | $12.1k | | 07/10/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 380.3k | $16.02 | $6.1M | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 857.8k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 20k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 44k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 7.5k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 7.6k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 6.8k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 166.9k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 332.5k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 398.8k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 937.5k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 38k | $15.54 | $590.1k | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 223.9k | $11.28 | $2.5M | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 344.8k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 223.9k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 56.5k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 38k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 43.7k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 36.1k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 53.1k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 12.5k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 2k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 485 | $0.00 | $0 | The 2000 Trust for Alexis Mae Hecht | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 223.2k | $0.00 | $0 | | 04/01/2019 |
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