| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Grant | Common Stock, par value $0.003 per share | 1.3k | $0.00 | $0 | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 341 | $344.48 | $117.5k | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 308 | $344.48 | $106.1k | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 217 | $344.48 | $74.8k | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 141 | $344.48 | $48.6k | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 54 | $344.48 | $18.6k | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 126 | $344.48 | $43.4k | | 01/31/2022 |
| 01/31/2022 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 193 | $344.48 | $66.5k | | 01/31/2022 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 350 | $475.34 | $166.4k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 1.5k | $476.47 | $733.8k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 1.6k | $477.65 | $763.8k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 650 | $478.87 | $311.3k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 150 | $481.13 | $72.2k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 350 | $483.57 | $169.2k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Exercise | Stock Option (right to buy) | 3.1k | $103.30 | $319.4k | | 08/10/2021 |
| 08/10/2021 | MARKETAXESS HOLDINGS INC | MKTX | Exercise | Stock Option (right to buy) | 1.5k | $156.85 | $242.6k | | 08/10/2021 |
| 05/26/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 2.6k | $462.07 | $1.2M | | 05/26/2021 |
| 05/26/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 1.4k | $462.89 | $640.6k | | 05/26/2021 |
| 05/26/2021 | MARKETAXESS HOLDINGS INC | MKTX | Exercise | Stock Option (right to buy) | 5k | $103.30 | $513.2k | | 05/26/2021 |
| 02/24/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 1.8k | $545.65 | $982.2k | | 02/24/2021 |
| 02/24/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 690 | $546.71 | $377.2k | | 02/24/2021 |
| 02/24/2021 | MARKETAXESS HOLDINGS INC | MKTX | Sale | Common Stock, par value $0.003 per share | 10 | $547.70 | $5.5k | | 02/24/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 426 | $540.76 | $230.4k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 466 | $540.76 | $252k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 1.3k | $540.76 | $688.9k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 52 | $540.76 | $28.1k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 123 | $540.76 | $66.5k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 135 | $540.76 | $73k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 175 | $540.76 | $94.6k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 104 | $540.76 | $56.2k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 209 | $540.76 | $113k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 1.5k | $540.76 | $836k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 143 | $540.76 | $77.3k | | 01/31/2021 |
| 01/31/2021 | MARKETAXESS HOLDINGS INC | MKTX | Payment of Exercise | Common Stock, par value $0.003 per share | 7 | $540.76 | $3.8k | | 01/31/2021 |
| 01/15/2021 | MARKETAXESS HOLDINGS INC | MKTX | Grant | Common Stock, par value $0.003 per share | 1.1k | $0.00 | $0 | | 01/15/2021 |
|