| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 04/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 04/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 05/21/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 9.3k | $0.00 | $0 | | 05/21/2022 |
| 05/21/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 14.4k | $1.77 | $25.5k | | 05/21/2022 |
| 04/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 4k | $0.00 | $0 | | 04/30/2022 |
| 04/24/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 10.6k | $0.00 | $0 | | 04/24/2021 |
| 04/26/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 3.5k | $0.00 | $0 | | 04/24/2020 |
| 04/24/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 10.6k | $0.00 | $0 | | 04/24/2020 |
| 04/24/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 18.1k | $1.86 | $33.7k | | 04/24/2020 |
| 04/26/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 3.5k | $0.00 | $0 | | 04/26/2019 |
| 04/26/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 6.5k | $5.67 | $37k | | 04/26/2019 |
| 04/27/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Common Stock | 2.6k | $0.00 | $0 | | 04/27/2018 |
| 04/27/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 2.9k | $7.80 | $22.3k | | 04/27/2018 |
| 04/30/2010 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 10k | $1.54 | $15.4k | | 04/30/2010 |