| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/26/2023 | Shin Barry | SVP, CFO | Payment of Exercise | Common Stock | 722 | $0.84 | $606.5 | | 06/26/2023 |
| 01/06/2023 | Shin Barry | SVP, CFO | Grant | Common Stock | 50k | $0.00 | $0 | | 01/06/2023 |
| 01/06/2023 | Yoder Robert T | SVP, Chief Business Officer | Grant | Common Stock | 25k | $0.00 | $0 | | 01/06/2023 |
| 01/06/2023 | Drake Patricia M. | SVP, Chief Commercial Officer | Grant | Common Stock | 25k | $0.00 | $0 | | 01/06/2023 |
| 01/06/2023 | Bourdow Carrie L. | President & CEO | Grant | Common Stock | 100k | $0.00 | $0 | | 01/06/2023 |
| 01/06/2023 | Demitrack Mark | SVP, Chief Medical Officer | Grant | Common Stock | 50k | $0.00 | $0 | | 01/06/2023 |
| 12/17/2022 | Demitrack Mark | SVP, Chief Medical Officer | Payment of Exercise | Common Stock | 497 | $1.55 | $770.4 | | 12/17/2022 |
| 12/17/2022 | Bourdow Carrie L. | President & CEO | Payment of Exercise | Common Stock | 1.3k | $1.55 | $2.1k | | 12/17/2022 |
| 12/17/2022 | Yoder Robert T | SVP, Chief Business Officer | Payment of Exercise | Common Stock | 443 | $1.55 | $686.6 | | 12/17/2022 |
| 12/17/2022 | Shin Barry | SVP, CFO | Payment of Exercise | Common Stock | 413 | $1.55 | $640.2 | | 12/17/2022 |
| 12/02/2022 | Yoder Robert T | SVP, Chief Business Officer | Payment of Exercise | Common Stock | 753 | $3.42 | $2.6k | | 12/02/2022 |
| 12/02/2022 | Shin Barry | SVP, CFO | Payment of Exercise | Common Stock | 1.2k | $3.42 | $4k | | 12/02/2022 |
| 12/02/2022 | Drake Patricia M. | SVP, Chief Commercial Officer | Payment of Exercise | Common Stock | 294 | $3.42 | $1k | | 12/02/2022 |
| 12/02/2022 | Bourdow Carrie L. | President & CEO | Payment of Exercise | Common Stock | 3.6k | $3.42 | $12.2k | | 12/02/2022 |
| 12/02/2022 | Demitrack Mark | SVP, Chief Medical Officer | Payment of Exercise | Common Stock | 1.1k | $3.42 | $3.8k | | 12/02/2022 |
| 11/10/2022 | Drake Patricia M. | SVP, Chief Commercial Officer | Payment of Exercise | Common Stock | 632 | $2.47 | $1.6k | | 11/10/2022 |
| 09/14/2022 | Shin Barry | SVP, CFO | Payment of Exercise | Common Stock | 1.8k | $0.21 | $369.2 | | 09/14/2022 |
| 06/28/2022 | Shin Barry | SVP, CFO | Sale | Common Stock | 31.8k | $0.41 | $13k | | 06/28/2022 |
| 06/09/2022 | Johnson Marvin | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | Braunstein Scott | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | Phillips Anne M. | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | Yanni Barbara | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | DOUGHERTY MICHAEL R | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | Nunn Jason Raleigh | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | MOULDER LEON O JR | Director | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 12/17/2021 | Demitrack Mark | SVP, Chief Medical Officer | Payment of Exercise | Common Stock | 12.4k | $0.70 | $8.7k | | 12/17/2021 |
| 12/17/2021 | Bourdow Carrie L. | President & CEO | Payment of Exercise | Common Stock | 33.5k | $0.70 | $23.5k | | 12/17/2021 |
| 12/17/2021 | Shin Barry | SVP, CFO | Payment of Exercise | Common Stock | 14.2k | $0.70 | $10k | | 12/17/2021 |
| 12/17/2021 | Yoder Robert T | SVP, Chief Business Officer | Payment of Exercise | Common Stock | 9.7k | $0.70 | $6.8k | | 12/17/2021 |
| 12/06/2021 | Yoder Robert T | SVP, Chief Business Officer | Payment of Exercise | Common Stock | 23k | $0.65 | $14.9k | | 12/06/2021 |
| 12/06/2021 | Shin Barry | SVP, CFO | Payment of Exercise | Common Stock | 34.4k | $0.65 | $22.4k | | 12/06/2021 |
| 12/06/2021 | Bourdow Carrie L. | President & CEO | Payment of Exercise | Common Stock | 93.6k | $0.65 | $60.8k | | 12/06/2021 |
| 12/06/2021 | Demitrack Mark | SVP, Chief Medical Officer | Payment of Exercise | Common Stock | 30.6k | $0.65 | $19.9k | | 12/06/2021 |
| 12/02/2021 | Demitrack Mark | SVP, Chief Medical Officer | Grant | Common Stock | 390k | $0.00 | $0 | | 12/02/2021 |
| 12/02/2021 | Bourdow Carrie L. | President & CEO | Grant | Common Stock | 1.2M | $0.00 | $0 | | 12/02/2021 |
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