| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/21/2021 | BEN-MAIMON CAROLE | Director | Grant | Restricted Stock Units | 150k | $0.00 | $0 | | 07/21/2021 |
| 07/21/2021 | Pate R Carter | Director | Grant | Restricted Stock Units | 150k | $0.00 | $0 | | 07/21/2021 |
| 07/21/2021 | Celentano John E | Director | Grant | Restricted Stock Units | 150k | $0.00 | $0 | | 07/21/2021 |
| 07/21/2021 | SABATINO THOMAS J JR | Director | Grant | Restricted Stock Units | 150k | $0.00 | $0 | | 07/21/2021 |
| 07/21/2021 | Marth William S | Director | Grant | Restricted Stock Units | 150k | $0.00 | $0 | | 07/21/2021 |
| 07/16/2021 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Payment of Exercise | Common Stock | 2.7k | $0.47 | $1.2k | | 07/16/2021 |
| 07/16/2021 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Exercise | Restricted Stock Units | 7.8k | $0.00 | $0 | | 07/16/2021 |
| 07/16/2021 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Payment of Exercise | Common Stock | 2.7k | $0.47 | $1.2k | | 07/16/2021 |
| 07/16/2021 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Exercise | Restricted Stock Units | 7.8k | $0.00 | $0 | | 07/16/2021 |
| 05/27/2021 | Pate R Carter | Director | Purchase | Common Stock | 30k | $0.55 | $16.5k | | 05/27/2021 |
| 04/15/2021 | De Paolantonio Ernest Robert | CFO | Grant | Stock Option | 240k | $0.57 | $136.8k | | 04/15/2021 |
| 04/15/2021 | De Paolantonio Ernest Robert | CFO | Grant | Restricted Stock Units | 195k | $0.00 | $0 | | 04/15/2021 |
| 03/11/2021 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Grant | Stock Option | 424k | $0.82 | $347.7k | | 03/11/2021 |
| 03/11/2021 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Grant | Restricted Stock Units | 344k | $0.00 | $0 | | 03/11/2021 |
| 02/22/2021 | Pate R Carter | Director | Grant | Stock Option | 2k | $1.11 | $2.2k | | 02/22/2021 |
| 02/16/2021 | Marth William S | Director | Grant | Stock Option | 2k | $1.36 | $2.7k | | 02/16/2021 |
| 01/04/2021 | SABATINO THOMAS J JR | Director | Grant | Stock Option | 2k | $0.74 | $1.5k | | 01/04/2021 |
| 01/04/2021 | BEN-MAIMON CAROLE | Director | Grant | Stock Option | 2k | $0.74 | $1.5k | | 01/04/2021 |
| 01/04/2021 | KOEHLER STEVEN H | Director | Grant | Stock Option | 2k | $0.74 | $1.5k | | 01/04/2021 |
| 01/04/2021 | CHAUDHURI BHASKAR | Director | Grant | Stock Option | 2k | $0.74 | $1.5k | | 01/04/2021 |
| 01/04/2021 | Celentano John E | Director | Grant | Stock Option | 2k | $0.74 | $1.5k | | 01/04/2021 |
| 08/26/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 475.5k | $1.24 | $591.3k | | 08/19/2020 |
| 08/26/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 85.1k | $1.25 | $106.2k | | 08/19/2020 |
| 08/25/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 84.8k | $1.13 | $96.1k | | 08/19/2020 |
| 08/25/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 15.2k | $1.13 | $17.1k | | 08/19/2020 |
| 08/21/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 103k | $1.66 | $171.1k | | 08/19/2020 |
| 08/21/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 18.4k | $1.66 | $30.5k | | 08/19/2020 |
| 08/19/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 74k | $2.26 | $167k | | 08/19/2020 |
| 08/19/2020 | LIFE SCIENCES OPPORTUNITIES FUND INSTITTUTIONAL II LP | 10% Owner | Sale | Common Stock | 13.3k | $2.25 | $29.8k | | 08/19/2020 |
| 07/16/2020 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Grant | Stock Option | 36.3k | $2.34 | $85k | | 07/16/2020 |
| 07/16/2020 | YACHMETZ PHILIP K | EVP, Chief Legal Off, Corp Sec | Grant | Restricted Stock Units | 23.5k | $0.00 | $0 | | 07/16/2020 |
| 03/02/2020 | Finio Damian | CFO | Grant | Stock Option | 263.6k | $0.44 | $116k | | 03/02/2020 |
| 02/04/2020 | Finio Damian | CFO | Grant | Stock Option | 250k | $0.39 | $97.5k | | 02/04/2020 |
| 02/04/2020 | Sawyer Timothy B. | CEO | Grant | Stock Option | 1.5M | $0.39 | $585k | | 02/04/2020 |
| 01/02/2020 | BEN-MAIMON CAROLE | Director | Grant | Stock Option | 20k | $0.42 | $8.3k | | 01/02/2020 |
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