| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/21/2022 | Rich Stuart | Chief Medical Officer | Gift | Common Stock | 1.9M | $0.00 | $0 | | 09/21/2022 |
| 09/21/2022 | Rich Stuart | Chief Medical Officer | Gift | Common Stock | 1.9M | $0.00 | $0 | By Stuart Rich 2022 Irrevocable Trust | 09/21/2022 |
| 08/11/2022 | Doogan Declan | 10% Owner | Gift | Common Stock | 567.9k | $0.00 | $0 | By Declan Doogan 2021 GRAT DTD 03-04-2021 | 08/11/2022 |
| 08/11/2022 | Doogan Declan | 10% Owner | Gift | Common Stock | 567.9k | $0.00 | $0 | | 08/11/2022 |
| 06/09/2022 | Almenoff June Sherie | Director | Grant | Stock Option (right to buy) | 5k | $0.62 | $3.1k | | 06/09/2022 |
| 06/09/2022 | PROEHL GERALD T | Director | Grant | Stock Option (right to buy) | 5k | $0.62 | $3.1k | | 06/09/2022 |
| 06/09/2022 | Rich Stuart | Chief Medical Officer | Grant | Stock Option (right to buy) | 100k | $0.62 | $62k | | 06/09/2022 |
| 06/09/2022 | Giordano Christopher Thomas | CEO | Grant | Stock Option (right to buy) | 200k | $0.62 | $124k | | 06/09/2022 |
| 06/09/2022 | Davidson Michael H. | Director | Grant | Stock Option (right to buy) | 5k | $0.62 | $3.1k | | 06/09/2022 |
| 06/09/2022 | Doogan Declan | 10% Owner | Grant | Stock Option (right to buy) | 5k | $0.62 | $3.1k | | 06/09/2022 |
| 06/09/2022 | Hunter Robyn | Director | Grant | Stock Option (right to buy) | 6.2k | $0.62 | $3.9k | | 06/09/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Disposition | Warrant (right to buy) | 4.8M | $1.97 | $9.4M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Warrant (right to buy) | 4.8M | $0.63 | $3M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Disposition | Series B Common Stock Purchase Warrants | 3.2M | $0.90 | $2.9M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Series B Common Stock Purchase Warrants | 3.2M | $0.90 | $2.9M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Disposition | Series C Common Stock Purchase Warrants | 4.6M | $0.90 | $4.2M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Series C Common Stock Purchase Warrants | 4.6M | $0.90 | $4.2M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Disposition | Common Stock Purchase Warrants | 2.4M | $1.04 | $2.5M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Common Stock Purchase Warrants | 2.4M | $0.63 | $1.5M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Disposition | Common Stock Purchase Warrants | 2.1M | $1.93 | $4M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Common Stock Purchase Warrants | 2.1M | $0.63 | $1.3M | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Pre-Funded Common Stock Purchase Warrants | 10.6M | $0.00 | $1.1k | See footnote | 05/18/2022 |
| 05/18/2022 | ARMISTICE CAPITAL, LLC | Director | Grant | Series C Common Stock Purchase Warrants | 10.6M | $0.63 | $6.7M | See footnote | 05/18/2022 |
| 11/29/2021 | Rich Stuart | Chief Medical Officer | Gift | Common stock | 1.9M | $0.00 | $0 | By Spouse | 10/12/2021 |
| 11/29/2021 | Rich Stuart | Chief Medical Officer | Gift | Common Stock | 1.9M | $0.00 | $0 | By Andrea Rich 2021 Irrevocable Trust | 10/12/2021 |
| 10/12/2021 | Rich Stuart | Chief Medical Officer | Gift | Common Stock | 1.9M | $0.00 | $0 | | 10/12/2021 |
| 10/12/2021 | Rich Stuart | Chief Medical Officer | Gift | Common stock | 1.9M | $0.00 | $0 | By Spouse | 10/12/2021 |
| 07/08/2021 | ARMISTICE CAPITAL, LLC | Director | Grant | Warrant (right to buy) | 4.8M | $0.00 | $477.3 | See Footnote | 07/08/2021 |
| 07/08/2021 | ARMISTICE CAPITAL, LLC | Director | Grant | Warrant (right to buy) | 4.8M | $1.97 | $9.4M | See Footnote | 07/08/2021 |
| 07/06/2021 | DiTonno Anthony A | CEO | Grant | Stock Option (right to buy) | 50k | $1.97 | $98.5k | | 07/06/2021 |
| 06/30/2021 | Doogan Declan | 10% Owner | Gift | Common Stock | 567.9k | $0.00 | $0 | | 06/30/2021 |
| 06/11/2021 | Doogan Declan | 10% Owner | Exercise | | 3.1k | $0.00 | $0 | | 06/10/2021 |
| 06/11/2021 | Rich Stuart | Chief Medical Officer | Exercise | Series B Preferred Stock | 3.6k | $0.00 | $0 | | 06/11/2021 |
| 06/11/2021 | Davidson Michael H. | Director | Grant | | 512k | $0.00 | $0 | | 06/11/2021 |
| 06/11/2021 | Davidson Michael H. | Director | Exercise | | 512 | $0.00 | $0 | | 06/11/2021 |
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