| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/10/2023 | Innoviva, Inc. | 10% Owner | Purchase | | 0 | $1.52 | $0 | See Footnotes | 01/10/2023 |
| 04/13/2022 | Odysseas Kostas D | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 04/13/2022 | PATTI JOSEPH M | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 04/13/2022 | Haimovitz Jules | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 04/13/2022 | Schlesinger Sarah J. | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 04/13/2022 | Kramer Robin | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 04/13/2022 | Morris Duane Alfred | VP of Operations | Grant | Stock Options (Right to Buy) | 41k | $5.11 | $209.5k | | 04/13/2022 |
| 04/13/2022 | Patrick Todd | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 04/13/2022 | Varnum Brian | President and CEO | Grant | Stock Options (Right to Buy) | 240k | $5.11 | $1.2M | | 04/13/2022 |
| 04/13/2022 | Peterson Todd C. | Director | Grant | Stock Options (Right to Buy) | 33k | $5.11 | $168.6k | | 04/13/2022 |
| 03/31/2022 | Innoviva, Inc. | 10% Owner | Purchase | Common Stock | 5.4M | $5.00 | $26.9M | See footnotes | 03/31/2022 |
| 03/31/2022 | Innoviva, Inc. | 10% Owner | Purchase | | 0 | $5.00 | $0 | See footnotes | 03/31/2022 |
| 02/09/2022 | Innoviva, Inc. | 10% Owner | Purchase | Common Stock | 3.6M | $5.00 | $18.1M | See footnotes | 02/09/2022 |
| 02/09/2022 | Innoviva, Inc. | 10% Owner | Purchase | | 1.8M | $5.00 | $9M | See footnotes | 02/09/2022 |
| 10/29/2021 | Innoviva, Inc. | 10% Owner | Purchase | Common Stock | 1.2M | $3.30 | $4M | See footnotes | 10/29/2021 |
| 08/02/2021 | Varnum Brian | President and CEO | Grant | Stock Option (Right to Buy) | 125k | $3.82 | $477.5k | | 08/02/2021 |
| 06/07/2021 | Peterson Todd C. | Director | Grant | Stock Option (Right to Buy) | 28k | $4.29 | $120.1k | | 06/07/2021 |
| 06/07/2021 | PATTI JOSEPH M | Director | Grant | Stock Option (Right to Buy) | 28k | $4.29 | $120.1k | | 06/07/2021 |
| 06/07/2021 | Kramer Robin | Director | Grant | Stock Option (Right to Buy) | 28k | $4.29 | $120.1k | | 06/07/2021 |
| 06/07/2021 | Schlesinger Sarah J. | Director | Grant | Stock Option (Right to Buy) | 28k | $4.29 | $120.1k | | 06/07/2021 |
| 06/07/2021 | Odysseas Kostas D | Director | Grant | Stock Option (Right to Buy) | 28k | $4.29 | $120.1k | | 06/07/2021 |
| 04/01/2021 | Haimovitz Jules | Director | Grant | Stock Option (Right to Buy) | 30k | $4.74 | $142.2k | | 04/01/2021 |
| 03/25/2021 | Martin Steven Robert | CFO | Grant | Stock Option (Right to Buy) | 56k | $5.14 | $287.8k | | 03/25/2021 |
| 03/25/2021 | Morris Duane Alfred | VP of Operations | Grant | Stock Option (Right to Buy) | 28k | $5.14 | $143.9k | | 03/25/2021 |
| 03/25/2021 | Varnum Brian | President and CEO | Grant | Stock Option (Right to Buy) | 112k | $5.14 | $575.7k | | 03/25/2021 |
| 03/25/2021 | Patrick Todd | Director | Grant | Stock Option (Right to Buy) | 112k | $5.14 | $575.7k | | 03/25/2021 |
| 03/17/2021 | Innoviva, Inc. | 10% Owner | Purchase | | 4.3M | $3.25 | $13.9M | See Footnotes | 03/17/2021 |
| 03/17/2021 | Innoviva, Inc. | 10% Owner | Purchase | | 4.3M | $3.25 | $13.9M | See Footnotes | 03/17/2021 |
| 01/26/2021 | Innoviva, Inc. | 10% Owner | Purchase | | 1.9M | $3.25 | $6.1M | See Footnotes | 01/26/2021 |
| 01/26/2021 | Innoviva, Inc. | 10% Owner | Purchase | | 1.9M | $3.25 | $6.1M | See Footnotes | 01/26/2021 |
| 12/08/2020 | BASTIANI RICHARD | Director | Grant | Stock Option (Right to Buy) | 23k | $3.15 | $72.4k | | 12/08/2020 |
| 12/08/2020 | Martin Steven Robert | CFO | Grant | Stock Option (Right to Buy) | 23k | $3.15 | $72.4k | | 12/08/2020 |
| 12/08/2020 | Varnum Brian | President and CEO | Grant | Stock Option (Right to Buy) | 23k | $3.15 | $72.4k | | 12/08/2020 |
| 12/08/2020 | Patrick Todd | Director | Grant | Stock Option (Right to Buy) | 23k | $3.15 | $72.4k | | 12/08/2020 |
| 12/08/2020 | Peterson Todd C. | Director | Grant | Stock Option (Right to Buy) | 23k | $3.15 | $72.4k | | 12/08/2020 |
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