| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/26/2023 | Unkart Edward W | Director | Grant | Stock Option (right to buy) | 10k | $10.08 | $100.8k | | 09/26/2023 |
| 09/26/2023 | Pereira Brian JG | Director | Grant | Stock Option (right to buy) | 10k | $10.08 | $100.8k | | 09/26/2023 |
| 09/26/2023 | Cha Albert | Director | Grant | Stock Option (right to buy) | 10k | $10.08 | $100.8k | | 09/26/2023 |
| 09/26/2023 | Stuart Nancy | Director | Grant | Stock Option (right to buy) | 10k | $10.08 | $100.8k | | 09/26/2023 |
| 09/26/2023 | Treanor Patrick | Director | Grant | Stock Option (right to buy) | 10k | $10.08 | $100.8k | | 09/26/2023 |
| 08/18/2023 | Audhya Paul K. | Chief Medical Officer | Sale | Common Stock | 8k | $10.73 | $86k | | 08/17/2023 |
| 08/18/2023 | Feener Edward P. | Chief Scientific Officer | Sale | Common Stock | 5k | $10.73 | $53.4k | | 08/17/2023 |
| 08/18/2023 | Yea Christopher | Chief Development Officer | Sale | Common Stock | 7.1k | $10.73 | $76.6k | | 08/17/2023 |
| 08/18/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Sale | Common Stock | 13.1k | $10.73 | $140.2k | | 08/17/2023 |
| 08/18/2023 | Crockett Thomas Andrew | CEO | Sale | Common Stock | 14.9k | $10.73 | $159.6k | | 08/17/2023 |
| 08/17/2023 | Crockett Thomas Andrew | CEO | Exercise | Restricted Stock Unit | 6.9k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Crockett Thomas Andrew | CEO | Exercise | Restricted Stock Unit | 5.8k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Crockett Thomas Andrew | CEO | Exercise | Performance Stock Unit | 20.8k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Exercise | Restricted Stock Unit | 6.9k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Exercise | Restricted Stock Unit | 2.4k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Exercise | Performance Stock Unit | 20.8k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Yea Christopher | Chief Development Officer | Exercise | Restricted Stock Unit | 1.8k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Yea Christopher | Chief Development Officer | Exercise | Restricted Stock Unit | 2.4k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Yea Christopher | Chief Development Officer | Exercise | Performance Stock Unit | 7.3k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Feener Edward P. | Chief Scientific Officer | Exercise | Restricted Stock Unit | 1.8k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Feener Edward P. | Chief Scientific Officer | Exercise | Restricted Stock Unit | 2.4k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Feener Edward P. | Chief Scientific Officer | Exercise | Performance Stock Unit | 7.3k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Audhya Paul K. | Chief Medical Officer | Exercise | Restricted Stock Unit | 2.4k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Audhya Paul K. | Chief Medical Officer | Exercise | Restricted Stock Unit | 4k | $0.00 | $0 | | 08/17/2023 |
| 08/17/2023 | Audhya Paul K. | Chief Medical Officer | Exercise | Performance Stock Unit | 12.1k | $0.00 | $0 | | 08/17/2023 |
| 05/18/2023 | Audhya Paul K. | Chief Medical Officer | Sale | Common Stock | 2.8k | $10.14 | $28.2k | | 01/11/2023 |
| 05/18/2023 | Feener Edward P. | Chief Scientific Officer | Sale | Common Stock | 1.8k | $10.14 | $18.1k | | 01/11/2023 |
| 05/18/2023 | Crockett Thomas Andrew | CEO | Sale | Common Stock | 5.6k | $10.14 | $57.1k | | 01/11/2023 |
| 05/18/2023 | Yea Christopher | Chief Development Officer | Sale | Common Stock | 2.6k | $10.14 | $26.4k | | 01/11/2023 |
| 05/18/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Sale | Common Stock | 4k | $10.14 | $41k | | 01/11/2023 |
| 05/18/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Grant | Employee Stock Option (Right to Buy) | 40k | $10.40 | $416k | | 05/18/2023 |
| 05/17/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Exercise | Restricted Stock Unit | 6.9k | $0.00 | $0 | | 01/11/2023 |
| 05/17/2023 | Palleiko Benjamin L | President, CFO, CBO & Sec'y | Exercise | Restricted Stock Unit | 2.4k | $0.00 | $0 | | 01/11/2023 |
| 05/17/2023 | Yea Christopher | Chief Development Officer | Exercise | Restricted Stock Unit | 2.4k | $0.00 | $0 | | 01/11/2023 |
| 05/17/2023 | Yea Christopher | Chief Development Officer | Exercise | Restricted Stock Unit | 1.8k | $0.00 | $0 | | 01/11/2023 |
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