| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 02/07/2019 | Payne Joseph E | President and CEO | Grant | Non-Qualified Stock Option (right to buy) | 60k | $4.99 | $299.4k | | 02/07/2019 |
| 02/07/2019 | Chivukula Pad | Chief Scientific Officer & COO | Grant | Non-Qualified Stock Option (right to buy) | 38.3k | $4.99 | $191.3k | | 02/07/2019 |
| 02/07/2019 | Chivukula Pad | Chief Scientific Officer & COO | Grant | Incentive Stock Option (right to buy) | 1.7k | $4.99 | $8.3k | | 02/07/2019 |
| 02/07/2019 | Kummerfeld Keith C | Vice President of Finance | Grant | Incentive Stock Option (right to buy) | 10k | $4.99 | $49.9k | | 02/07/2019 |