| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/26/2023 | BIOGEN INC. | 10% Owner | Sale | Common Stock | 6M | $0.50 | $3M | By Biogen MA Inc. | 09/26/2023 |
| 08/13/2023 | Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Payment of Exercise | Common Stock | 864 | $1.08 | $933.1 | | 08/13/2023 |
| 06/01/2023 | Beers Courtney | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Beers Courtney | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | Carey Robert | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Carey Robert | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | Hillan Kenneth J. | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Hillan Kenneth J. | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | Horn Margaret A | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Horn Margaret A | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | Markels John | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Markels John | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | Meyers James R | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Meyers James R | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | PARKER H STEWART | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | PARKER H STEWART | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 06/01/2023 | Smith Karen L. | Director | Grant | Common Stock | 13.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Smith Karen L. | Director | Grant | Stock Option (Right to Buy) | 27.8k | $1.11 | $30.8k | | 06/01/2023 |
| 05/25/2023 | Macrae Sandy | President, CEO and Director | Payment of Exercise | Common Stock | 10.4k | $1.33 | $13.8k | | 05/25/2023 |
| 05/25/2023 | Duraibabu Prathyusha | SVP, CFO | Payment of Exercise | Common Stock | 1.3k | $1.33 | $1.8k | | 05/25/2023 |
| 05/25/2023 | Fontenot Jason D. | SVP, Chief Scientific Officer | Payment of Exercise | Common Stock | 1k | $1.33 | $1.4k | | 05/25/2023 |
| 05/25/2023 | Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Payment of Exercise | Common Stock | 1.5k | $1.33 | $1.9k | | 05/25/2023 |
| 05/25/2023 | McClung David Mark | EVP, COO | Payment of Exercise | Common Stock | 1.9k | $1.33 | $2.6k | | 05/25/2023 |
| 05/25/2023 | Ramelmeier Rolf Andrew | EVP, Technical Operations | Payment of Exercise | Common Stock | 1.8k | $1.33 | $2.3k | | 05/25/2023 |
| 05/25/2023 | Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Payment of Exercise | Common Stock | 1.3k | $1.33 | $1.8k | | 05/25/2023 |
| 02/25/2023 | McClung David Mark | EVP, COO | Payment of Exercise | Common Stock | 9.7k | $2.66 | $25.9k | | 02/24/2023 |
| 02/25/2023 | Ramelmeier Rolf Andrew | EVP, Technical Operations | Payment of Exercise | Common Stock | 15.6k | $2.66 | $41.5k | | 02/24/2023 |
| 02/25/2023 | Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Payment of Exercise | Common Stock | 5.1k | $2.66 | $13.6k | | 02/24/2023 |
| 02/25/2023 | Macrae Sandy | President, CEO and Director | Payment of Exercise | Common Stock | 54.8k | $2.66 | $145.7k | | 02/24/2023 |
| 02/25/2023 | Duraibabu Prathyusha | SVP, CFO | Payment of Exercise | Common Stock | 7k | $2.66 | $18.7k | | 02/24/2023 |
| 02/25/2023 | Fontenot Jason D. | SVP, Chief Scientific Officer | Payment of Exercise | Common Stock | 6.6k | $2.66 | $17.4k | | 02/24/2023 |
| 02/25/2023 | Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Payment of Exercise | Common Stock | 9.8k | $2.66 | $26.2k | | 02/24/2023 |
| 02/24/2023 | Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Grant | Stock Option (Right to Buy) | 249.4k | $2.66 | $663.3k | | 02/24/2023 |
| 02/24/2023 | Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Grant | Common Stock | 53.4k | $0.00 | $0 | | 02/24/2023 |
| 02/24/2023 | McClung David Mark | EVP, COO | Grant | Common Stock | 56.2k | $0.00 | $0 | | 02/24/2023 |
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