| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/08/2023 | Merus N.V. | MRUS | Grant | Share option (right to buy) | 14.4k | $23.29 | $335.7k | | 06/08/2023 |
| 06/02/2023 | Aclaris Therapeutics, Inc. | ACRS | Exercise | Restricted Stock Units | 4.5k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Aclaris Therapeutics, Inc. | ACRS | Grant | Stock Option (Right to Buy) | 15.8k | $8.70 | $137k | | 06/01/2023 |
| 06/01/2023 | Aclaris Therapeutics, Inc. | ACRS | Grant | Restricted Stock Units | 4.7k | $0.00 | $0 | | 06/01/2023 |
| 06/03/2022 | Aclaris Therapeutics, Inc. | ACRS | Exercise | Restricted Stock Units | 3.4k | $0.00 | $0 | | 06/02/2022 |
| 06/02/2022 | Aclaris Therapeutics, Inc. | ACRS | Grant | Stock Option (Right to Buy) | 15.8k | $14.48 | $228.1k | | 06/02/2022 |
| 06/02/2022 | Aclaris Therapeutics, Inc. | ACRS | Grant | Restricted Stock Units | 4.5k | $0.00 | $0 | | 06/02/2022 |
| 05/31/2022 | Merus N.V. | MRUS | Grant | Share option (right to buy) | 16.6k | $18.56 | $308.2k | | 05/31/2022 |
| 06/03/2021 | Aclaris Therapeutics, Inc. | ACRS | Grant | Stock Option (Right to Buy) | 12.2k | $21.90 | $268.3k | | 06/03/2021 |
| 06/03/2021 | Aclaris Therapeutics, Inc. | ACRS | Grant | Restricted Stock Units | 3.4k | $0.00 | $0 | | 06/03/2021 |
| 05/28/2021 | Merus N.V. | MRUS | Grant | Share option (right to buy) | 6.1k | $21.15 | $129.4k | | 05/28/2021 |
| 02/02/2021 | Aclaris Therapeutics, Inc. | ACRS | Exercise | Option Grant (right to buy) | 8k | $18.35 | $146.8k | | 02/02/2021 |
| 02/02/2021 | Aclaris Therapeutics, Inc. | ACRS | Exercise | Option Grant (right to buy) | 6.6k | $18.32 | $121.5k | | 02/02/2021 |
| 06/30/2020 | Merus N.V. | MRUS | Grant | Share Option (right to buy) | 8.6k | $16.09 | $138.9k | | 06/30/2020 |
| 06/06/2020 | Aclaris Therapeutics, Inc. | ACRS | Exercise | Restricted Stock Units | 7.3k | $0.00 | $0 | | 06/04/2020 |
| 06/04/2020 | Aclaris Therapeutics, Inc. | ACRS | Grant | Option Grant (right to buy) | 16.5k | $1.41 | $23.3k | | 06/04/2020 |
| 03/02/2020 | Aclaris Therapeutics, Inc. | ACRS | Grant | Restricted stock units | 8.9k | $0.00 | $0 | | 03/02/2020 |
| 03/02/2020 | Aclaris Therapeutics, Inc. | ACRS | Exercise | Restricted stock units | 8.9k | $0.00 | $0 | | 03/02/2020 |
| 12/17/2019 | Spark Therapeutics, Inc. | ONCE | Other | Common Stock | 40.2k | $114.50 | $4.6M | | 12/17/2019 |
| 12/17/2019 | Spark Therapeutics, Inc. | ONCE | Other | Common Stock | 481.3k | $114.50 | $55.1M | See Footnote | 12/17/2019 |
| 12/17/2019 | Spark Therapeutics, Inc. | ONCE | Disposition | Stock Option (Right to Buy) | 4k | $81.53 | $326.1k | | 12/17/2019 |
| 12/17/2019 | Spark Therapeutics, Inc. | ONCE | Disposition | Stock Option (Right to Buy) | 4k | $50.93 | $203.7k | | 12/17/2019 |
| 12/17/2019 | Spark Therapeutics, Inc. | ONCE | Disposition | Stock Option (Right to Buy) | 6k | $56.22 | $337.3k | | 12/17/2019 |
| 06/06/2019 | Aclaris Therapeutics, Inc. | ACRS | Grant | Restricted Stock Units | 7.3k | $0.00 | $0 | | 06/06/2019 |
| 05/30/2019 | Spark Therapeutics, Inc. | ONCE | Exercise | Restricted Stock Units | 1.5k | $0.00 | $0 | | 05/30/2019 |
| 01/04/2019 | Spark Therapeutics, Inc. | ONCE | Exercise | Stock Option (right to buy) | 37.2k | $3.45 | $128.4k | | 01/04/2019 |
| 10/22/2018 | Aclaris Therapeutics, Inc. | ACRS | Purchase | Common Stock | 372.1k | $10.75 | $4M | See Footnote | 10/22/2018 |
| 06/07/2018 | Aclaris Therapeutics, Inc. | ACRS | Grant | Stock Option (right to buy) | 8k | $18.35 | $146.8k | | 06/07/2018 |
| 05/31/2018 | Spark Therapeutics, Inc. | ONCE | Exercise | Restricted Stock Units | 1.5k | $0.00 | $0 | | 05/30/2018 |
| 05/30/2018 | Spark Therapeutics, Inc. | ONCE | Grant | Stock Option (right to buy) | 4k | $81.53 | $326.1k | | 05/30/2018 |
| 05/30/2018 | Spark Therapeutics, Inc. | ONCE | Grant | Restricted Stock Units | 1.5k | $0.00 | $0 | | 05/30/2018 |
| 07/24/2017 | Spark Therapeutics, Inc. | ONCE | Sale | Common Stock | 199.3k | $70.04 | $14M | See footnote | 07/24/2017 |
| 07/24/2017 | Spark Therapeutics, Inc. | ONCE | Sale | Common Stock | 7.4k | $71.59 | $526.2k | See footnote | 07/24/2017 |
| 07/24/2017 | Spark Therapeutics, Inc. | ONCE | Sale | Common Stock | 4.7k | $72.28 | $338.2k | See footnote | 07/24/2017 |
| 07/24/2017 | Spark Therapeutics, Inc. | ONCE | Sale | Common Stock | 518 | $73.10 | $37.9k | See footnote | 07/24/2017 |
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