| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/31/2023 | Bhanji Muna | Director | Sale | Common Stock | 265 | $42.33 | $11.2k | | 07/31/2023 |
| 07/06/2023 | Bhanji Muna | Director | Sale | Common Stock | 1.9k | $39.30 | $73.4k | | 07/06/2023 |
| 07/03/2023 | Clark Eliana | EVP, Chief Technical Officer | Sale | Common Stock | 360 | $40.51 | $14.6k | | 07/03/2023 |
| 06/14/2023 | Bhanji Muna | Director | Grant | | 4.4k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | Bhanji Muna | Director | Grant | Stock Option (right to buy) | 6.5k | $45.20 | $292.6k | | 06/14/2023 |
| 06/14/2023 | GOODMAN JESSE | Director | Grant | | 4.4k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | GOODMAN JESSE | Director | Grant | Stock Option (right to buy) | 6.5k | $45.20 | $292.6k | | 06/14/2023 |
| 06/14/2023 | Keresty Georgia | Director | Grant | | 4.4k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | Keresty Georgia | Director | Grant | Stock Option (right to buy) | 6.5k | $45.20 | $292.6k | | 06/14/2023 |
| 06/14/2023 | Crowley John F | Director | Grant | | 4.4k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | Crowley John F | Director | Grant | Stock Option (right to buy) | 6.5k | $45.20 | $292.6k | | 06/14/2023 |
| 06/14/2023 | Cohen Fred E | Director | Grant | | 4.4k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | Cohen Fred E | Director | Grant | Stock Option (right to buy) | 6.5k | $45.20 | $292.6k | | 06/14/2023 |
| 06/14/2023 | Verwiel Frank | Director | Grant | | 4.4k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | Verwiel Frank | Director | Grant | Stock Option (right to buy) | 6.5k | $45.20 | $292.6k | | 06/14/2023 |
| 06/14/2023 | CHASE WILLIAM J | Director | Grant | | 1.7k | $0.00 | $0 | | 06/14/2023 |
| 06/14/2023 | CHASE WILLIAM J | Director | Grant | Stock Option (right to buy) | 2.4k | $45.20 | $110.6k | | 06/14/2023 |
| 01/05/2023 | Sepp-Lorenzino Laura | EVP, Chief Scientific Officer | Sale | Common Stock | 1.6k | $38.22 | $62.7k | | 01/04/2023 |
| 01/05/2023 | Sepp-Lorenzino Laura | EVP, Chief Scientific Officer | Sale | Common Stock | 689 | $39.10 | $26.9k | | 01/04/2023 |
| 01/04/2023 | BASTA JAMES | EVP, General Counsel | Sale | Common Stock | 1.1k | $37.21 | $42.3k | | 01/04/2023 |
| 01/04/2023 | Lebwohl David | EVP, Chief Medical Officer | Sale | Common Stock | 2.6k | $37.21 | $95.8k | | 01/04/2023 |
| 01/04/2023 | Clark Eliana | EVP, Chief Technical Officer | Sale | Common Stock | 1.7k | $37.21 | $63k | | 07/01/2022 |
| 01/04/2023 | Hicks Derek | EVP, Chief Business Officer | Sale | Common Stock | 1.8k | $37.21 | $67.4k | | 01/04/2023 |
| 01/04/2023 | Sepp-Lorenzino Laura | EVP, Chief Scientific Officer | Sale | Common Stock | 2.5k | $37.21 | $93.3k | | 01/04/2023 |
| 01/04/2023 | Goddard Glenn | EVP, CFO | Sale | Common Stock | 2.4k | $37.21 | $90.3k | | 01/04/2023 |
| 01/04/2023 | LEONARD JOHN M | President and CEO | Sale | Common Stock | 6.7k | $37.21 | $248.3k | | 01/04/2023 |
| 01/03/2023 | Clark Eliana | EVP, Chief Technical Officer | Sale | Common Stock | 231 | $34.48 | $8k | | 07/01/2022 |
| 01/01/2023 | Lebwohl David | EVP, Chief Medical Officer | Exercise | Restricted Stock Unit | 3.2k | $0.00 | $0 | | 01/01/2023 |
| 01/01/2023 | Sepp-Lorenzino Laura | EVP, Chief Scientific Officer | Exercise | Restricted Stock Unit | 3.5k | $0.00 | $0 | | 01/01/2023 |
| 01/01/2023 | Goddard Glenn | EVP, CFO | Exercise | Restricted Stock Unit | 3.1k | $0.00 | $0 | | 01/01/2023 |
| 01/01/2023 | LEONARD JOHN M | President and CEO | Exercise | Restricted Stock Unit | 7.8k | $0.00 | $0 | | 01/01/2023 |
| 07/01/2022 | Clark Eliana | EVP, Chief Technical Officer | Sale | Common Stock | 105 | $51.74 | $5.4k | | 07/01/2022 |
| 06/14/2022 | Bhanji Muna | Director | Grant | | 2k | $0.00 | $0 | | 06/14/2022 |
| 06/14/2022 | Bhanji Muna | Director | Grant | Stock Option (right to buy) | 3k | $38.49 | $114.7k | | 06/14/2022 |
| 06/14/2022 | Keresty Georgia | Director | Grant | | 5.2k | $0.00 | $0 | | 06/14/2022 |
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