| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/29/2017 | Koninklijke DSM N.V. | 10% Owner | Other | Ordinary Shares | 48.7M | $35.00 | $1704.4M | | 08/29/2017 |
| 08/29/2017 | MULLEN JAMES C | CEO | Other | Restricted Stock Units (Ordinary Shares) | 93.4k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | MULLEN JAMES C | CEO | Other (disposition) | Restricted Stock Units (Ordinary Shares) | 906.9k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | MULLEN JAMES C | CEO | Other | Ordinary Shares | 2.6M | $35.00 | $91.5M | By Patheon Holdco Cooperatief U.A. on behalf of the reporting person | 08/29/2017 |
| 08/29/2017 | MULLEN JAMES C | CEO | Disposition | Options (Right to Buy) | 242.9k | $26.49 | $6.4M | | 08/29/2017 |
| 08/29/2017 | HASLER HANS PETER | Director | Other | Restricted Stock Units (Ordinary Shares) | 16.9k | $35.00 | $590.2k | | 08/29/2017 |
| 08/29/2017 | Hayes William B | Director | Other | Restricted Stock Units (Ordinary Shares) | 17.4k | $35.00 | $610.6k | | 08/29/2017 |
| 08/29/2017 | McMullen Jeffrey P | Director | Other | Restricted Stock Units (Ordinary Shares) | 27.4k | $35.00 | $960.6k | | 08/29/2017 |
| 08/29/2017 | New Rebecca Holland | EVP, Enterprise Operations | Other | Restricted Stock Units (Ordinary Shares) | 10.3k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | New Rebecca Holland | EVP, Enterprise Operations | Other (disposition) | Restricted Stock Units (Ordinary Shares) | 161.5k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | New Rebecca Holland | EVP, Enterprise Operations | Other | Ordinary Shares | 286.6k | $35.00 | $10M | By Patheon Holdco Cooperatief U.A. on behalf of the reporting person | 08/29/2017 |
| 08/29/2017 | New Rebecca Holland | EVP, Enterprise Operations | Disposition | Options (Right to Buy) | 26.8k | $26.49 | $709.7k | | 08/29/2017 |
| 08/29/2017 | Gill Harry R III | SVP, Quality/Continuous Imprvt | Other | Restricted Stock Units (Ordinary Shares) | 7.1k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Gill Harry R III | SVP, Quality/Continuous Imprvt | Other (disposition) | Restricted Stock Units (Ordinary Shares) | 105.8k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Gill Harry R III | SVP, Quality/Continuous Imprvt | Other | Ordinary Shares | 305.1k | $35.00 | $10.7M | By Patheon Holdco Cooperatief U.A. on behalf of the reporting person | 08/29/2017 |
| 08/29/2017 | Gill Harry R III | SVP, Quality/Continuous Imprvt | Disposition | Options (Right to Buy) | 18.4k | $26.49 | $487.4k | | 08/29/2017 |
| 08/29/2017 | Cogut Charles I | Director | Other | Restricted Stock Units (Ordinary Shares) | 4.1k | $35.00 | $142.1k | | 08/29/2017 |
| 08/29/2017 | Pisano Gary P. | Director | Other | Restricted Stock Units (Ordinary Shares) | 17.4k | $35.00 | $610.6k | | 08/29/2017 |
| 08/29/2017 | Eykerman Philip | Director | Other | Ordinary Shares | 28k | $35.00 | $980k | | 08/29/2017 |
| 08/29/2017 | Tanda Stephan B. | Director | Other | Restricted Stock Units (Ordinary Shares) | 4.7k | $35.00 | $163.1k | | 08/29/2017 |
| 08/29/2017 | Negron Francisco R. | President, Drug Product Svcs | Other | Restricted Stock Units (Ordinary Shares) | 11.2k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Negron Francisco R. | President, Drug Product Svcs | Other (disposition) | Restricted Stock Units (Ordinary Shares) | 261.3k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Negron Francisco R. | President, Drug Product Svcs | Other | Ordinary Shares | 330.2k | $35.00 | $11.6M | By Patheon Holdco Cooperatief U.A. on behalf of the reporting person | 08/29/2017 |
| 08/29/2017 | Negron Francisco R. | President, Drug Product Svcs | Disposition | Options (Right to Buy) | 29.2k | $26.49 | $773.4k | | 08/29/2017 |
| 08/29/2017 | Utiger Lukas | President, Drug Substance Svcs | Other | Restricted Stock Units (Ordinary Shares) | 12.4k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Utiger Lukas | President, Drug Substance Svcs | Other (disposition) | Restricted Stock Units (Ordinary Shares) | 191.8k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Utiger Lukas | President, Drug Substance Svcs | Other | Ordinary Shares | 373.8k | $35.00 | $13.1M | By Patheon Holdco Cooperatief U.A. on behalf of the reporting person | 08/29/2017 |
| 08/29/2017 | Utiger Lukas | President, Drug Substance Svcs | Disposition | Options (Right to Buy) | 32.3k | $26.49 | $855.3k | | 08/29/2017 |
| 08/29/2017 | Sherbet Eric | General Counsel and Secretary | Other (disposition) | Restricted Stock Units (Ordinary Shares) | 219.3k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Sherbet Eric | General Counsel and Secretary | Other | Ordinary Shares | 129.6k | $35.00 | $4.5M | By Patheon Holdco Cooperatief U.A. on behalf of the reporting person | 08/29/2017 |
| 08/29/2017 | Sherbet Eric | General Counsel and Secretary | Disposition | Options (Right to Buy) | 32.6k | $26.49 | $864.4k | | 08/29/2017 |
| 08/29/2017 | Sherbet Eric | General Counsel and Secretary | Other | Restricted Stock Units (Ordinary Shares) | 12.6k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Torres Raul Cardona | SVP, Quality | Other | Ordinary Shares | 13.1k | $0.00 | $0 | | 08/29/2017 |
| 08/29/2017 | Torres Raul Cardona | SVP, Quality | Disposition | Options (Right to Buy) | 21.8k | $21.00 | $457.5k | | 08/29/2017 |
| 08/29/2017 | Torres Raul Cardona | SVP, Quality | Disposition | Options (Right to Buy) | 17.2k | $26.49 | $454.9k | | 08/29/2017 |
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