| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 11/17/2006 | Dickinson Andrew D | Former VP, Gen. Counsel & Sec | Disposition | Common Stock | 626 | $0.00 | $0 | | 11/17/2006 |
| 11/17/2006 | GERBER MICHAEL J | Former SVP Clin Dev & Reg Aff | Disposition | Common Stock | 7.9k | $0.00 | $0 | | 11/17/2006 |
| 11/17/2006 | MITCHELL DANIEL J | Director | Disposition | Common Stock Warrant (right to buy) | 149.1k | $7.80 | $1.2M | By Sequel Limited Partnership III | 11/17/2006 |
| 11/17/2006 | MITCHELL DANIEL J | Director | Disposition | Common Stock Warrant (right to buy) | 4.1k | $7.80 | $32.3k | By Sequel Entrepreneurs Fund III, L.P. | 11/17/2006 |
| 11/17/2006 | FREYTAG J WILLIAM | Former Chairman, Pres & CEO | Disposition | Common Stock | 2k | $0.00 | $0 | | 11/17/2006 |
| 11/17/2006 | FREYTAG J WILLIAM | Former Chairman, Pres & CEO | Disposition | Common Stock | 15k | $0.00 | $0 | By J. William Freytag Trust, as co-trustee with spouse | 11/17/2006 |
| 11/17/2006 | ORONSKY ARNOLD L | Director | Disposition | Common Stock | 17.5k | $0.00 | $0 | | 11/17/2006 |
| 11/17/2006 | ORONSKY ARNOLD L | Director | Disposition | Common Stock Warrant (right to buy) | 118.3k | $7.80 | $922.6k | By InterWest Partners VIII, LP | 11/17/2006 |
| 11/17/2006 | ORONSKY ARNOLD L | Director | Disposition | Common Stock Warrant (right to buy) | 944 | $7.80 | $7.4k | By InterWest Investors VIII, LP | 11/17/2006 |
| 11/17/2006 | ORONSKY ARNOLD L | Director | Disposition | Common Stock Warrant (right to buy) | 3.4k | $7.80 | $26.4k | By InterWest Investors Q VIII, LP | 11/17/2006 |
| 11/17/2006 | ORONSKY ARNOLD L | Director | Disposition | Common Stock Warrant (right to buy) | 29.7k | $7.80 | $231.8k | By InterWest Partners VI, LP | 11/17/2006 |
| 11/17/2006 | ORONSKY ARNOLD L | Director | Disposition | Common Stock Warrant (right to buy) | 932 | $7.80 | $7.3k | By InterWest Investors VI, LP | 11/17/2006 |
| 11/17/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Common Stock | 2.6k | $0.00 | $0 | | 11/17/2006 |
| 11/17/2006 | CASPARI ROBERT FREDERICK | Former SVP, Comm Operations | Disposition | Common Stock | 92 | $0.00 | $0 | | 11/17/2006 |
| 11/17/2006 | GORCZYNSKI RICHARD J | Former SVP of R&D | Disposition | Common Stock | 1.9k | $0.00 | $0 | | 11/17/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Other | Common Stock | 15.2k | $0.00 | $0 | By Savacor Trust, as co-trustee | 11/14/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Disposition | Stock Option (right to buy) | 120k | $1.25 | $150k | | 11/14/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Disposition | Stock Option (right to buy) | 5.5k | $1.25 | $6.8k | | 11/14/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Disposition | Stock Option (right to buy) | 4.1k | $1.25 | $5.1k | | 11/14/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Disposition | Stock Option (right to buy) | 41.6k | $5.00 | $207.8k | | 11/14/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Disposition | Stock Option (right to buy) | 58.4k | $5.00 | $292.2k | | 11/14/2006 |
| 11/14/2006 | CASPARI ROBERT FREDERICK | Former SVP, Comm Operations | Disposition | Stock Option (right to buy) | 9.8k | $40.98 | $400k | | 11/14/2006 |
| 11/14/2006 | Dickinson Andrew D | Former VP, Gen. Counsel & Sec | Disposition | Stock Option (right to buy) | 1.8k | $8.48 | $14.8k | | 11/14/2006 |
| 11/14/2006 | Dickinson Andrew D | Former VP, Gen. Counsel & Sec | Disposition | Stock Option (right to buy) | 9.8k | $38.28 | $376.5k | | 11/14/2006 |
| 11/14/2006 | Dickinson Andrew D | Former VP, Gen. Counsel & Sec | Disposition | Stock Option (right to buy) | 38.2k | $38.28 | $1.5M | | 11/14/2006 |
| 11/14/2006 | ORONSKY ARNOLD L | Director | Disposition | Stock Option (right to buy) | 10k | $32.45 | $324.5k | | 11/13/2006 |
| 11/14/2006 | BRISTOW MICHAEL R | Director | Disposition | Stock Option (right to buy) | 11.5k | $8.48 | $97.8k | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Other | Common Stock | 73.5k | $0.00 | $0 | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Stock Option (right to buy) | 11.4k | $5.00 | $57k | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Stock Option (right to buy) | 16.7k | $5.00 | $83.4k | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Stock Option (right to buy) | 20.3k | $8.48 | $172.1k | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Stock Option (right to buy) | 32k | $8.48 | $271.4k | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Stock Option (right to buy) | 6.8k | $38.28 | $259.8k | | 11/14/2006 |
| 11/14/2006 | TURNER JOSEPH L | Frmr SVP Fin Admin CFO Treas | Disposition | Stock Option (right to buy) | 30.7k | $38.28 | $1.2M | | 11/14/2006 |
| 11/14/2006 | JACKSON JERRY T | Director | Disposition | Stock Option (right to buy) | 22k | $1.25 | $27.5k | | 11/14/2006 |
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