| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/06/2023 | Reneo Pharmaceuticals, Inc. | RPHM | Grant | Stock Option (right to buy) | 17.5k | $9.01 | $157.7k | | 06/06/2023 |
| 05/25/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | Grant | Stock Option (Right to Buy) | 30k | $2.26 | $67.8k | | 05/25/2023 |
| 06/13/2022 | EXICURE, INC. | XCUR | Grant | Employee Stock Option (right to buy) | 50k | $0.13 | $6.3k | | 06/13/2022 |
| 06/01/2022 | Reneo Pharmaceuticals, Inc. | RPHM | Grant | Stock Option (right to buy) | 17.5k | $2.09 | $36.6k | | 06/01/2022 |
| 05/25/2022 | SPRUCE BIOSCIENCES, INC. | SPRB | Grant | Stock Option (Right to Buy) | 22.5k | $1.32 | $29.7k | | 05/25/2022 |
| 07/14/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 111.7k | $8.50 | $949.8k | By Abingworth Bioventures 8 LP | 07/14/2021 |
| 06/23/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 20.7k | $9.28 | $192.2k | By Abingworth Bioventures 8 LP | 06/23/2021 |
| 06/22/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 14.6k | $8.72 | $127.5k | By Abingworth Bioventures 8 LP | 06/21/2021 |
| 06/21/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 32.7k | $9.03 | $294.9k | By Abingworth Bioventures 8 LP | 06/21/2021 |
| 06/08/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 16.6k | $9.50 | $157.7k | By Abingworth Bioventures 8 LP | 06/08/2021 |
| 06/04/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 257 | $9.42 | $2.4k | By Abingworth Bioventures 8 LP | 06/03/2021 |
| 06/03/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 12.1k | $9.25 | $111.9k | By Abingworth Bioventures 8 LP | 06/03/2021 |
| 06/02/2021 | EXICURE, INC. | XCUR | Grant | Stock Option (right to buy) | 50k | $1.71 | $85.5k | | 06/02/2021 |
| 05/28/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 14 | $9.50 | $133 | By Abingworth Bioventures 8 LP | 05/28/2021 |
| 05/27/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 1.1k | $9.26 | $10.4k | By Abingworth Bioventures 8 LP | 05/26/2021 |
| 05/26/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 5.9k | $9.38 | $55.5k | By Abingworth Bioventures 8 LP | 05/26/2021 |
| 05/20/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | Grant | Stock Option (Right to Buy) | 10k | $15.24 | $152.4k | | 05/20/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Conversion | Series B Preferred Stock | 7.4M | $0.00 | $0 | By Abingworth Bioventures 8 LP | 04/13/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 200k | $15.00 | $3M | By Abingworth Bioventures 8 LP | 04/13/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Conversion | Common Stock | 1.7M | $0.00 | $0 | By Abingworth Bioventures 8 LP | 04/13/2021 |
| 04/08/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Grant | Stock Option (right to buy) | 14k | $15.00 | $210k | | 04/08/2021 |
| 10/14/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | Purchase | Common Stock | 200k | $15.00 | $3M | See Footnotes | 10/14/2020 |
| 10/14/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | Conversion | Common Stock | 1.6M | $0.00 | $0 | See Footnotes | 10/14/2020 |
| 10/14/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | Conversion | Series B Preferred Stock | 10.4M | $0.00 | $0 | See Footnotes | 10/14/2020 |
| 06/04/2020 | EXICURE, INC. | XCUR | Grant | Stock Option (right to buy) | 21.7k | $2.79 | $60.5k | | 06/04/2020 |
| 08/02/2019 | EXICURE, INC. | XCUR | Grant | Stock option (right to buy) | 43.4k | $2.95 | $128k | | 08/02/2019 |