| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/08/2023 | RHOADS ANN D | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | SCHAFER CAROL | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | Foley Todd | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | Molineaux Susan | Director | Grant | Stock Option (right to buy) | 76.2k | $11.66 | $888.5k | | 06/08/2023 |
| 06/08/2023 | Bonita David P | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | Kulkarni Samarth | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | Morrison Briggs | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | Civik Thomas | Director | Grant | Stock Option (right to buy) | 27.2k | $11.66 | $317.2k | | 06/08/2023 |
| 06/08/2023 | Zinda Michael | EVP, Chief Scientific Officer | Sale | Common Shares | 2.9k | $12.02 | $34.5k | | 06/07/2023 |
| 06/07/2023 | Zinda Michael | EVP, Chief Scientific Officer | Sale | Common Shares | 6.4k | $12.03 | $77k | | 06/07/2023 |
| 06/06/2023 | Zinda Michael | EVP, Chief Scientific Officer | Sale | Common Shares | 1.2k | $12.04 | $14.4k | | 06/06/2023 |
| 01/30/2023 | Segal Lloyd Mitchell | President and CEO | Grant | Common Shares | 78.6k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Segal Lloyd Mitchell | President and CEO | Grant | Employee Stock Option (right to buy) | 344.2k | $12.42 | $4.3M | | 01/30/2023 |
| 01/30/2023 | Koehler Maria | EVP, Chief Medical Officer | Grant | Common Shares | 26.4k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Koehler Maria | EVP, Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 119.2k | $12.42 | $1.5M | | 01/30/2023 |
| 01/30/2023 | Forte Steve | EVP, CFO | Grant | Common Shares | 24.5k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Forte Steve | EVP, CFO | Grant | Employee Stock Option (right to buy) | 111k | $12.42 | $1.4M | | 01/30/2023 |
| 01/30/2023 | Zinda Michael | EVP, Chief Scientific Officer | Grant | Common Shares | 24.6k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Zinda Michael | EVP, Chief Scientific Officer | Grant | Employee Stock Option (right to buy) | 97.1k | $12.42 | $1.2M | | 01/30/2023 |
| 12/29/2022 | Jerel Davis | Director | Other (disposition) | Common Shares | 287.2k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (acquisition) | Common Shares | 62k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (disposition) | Common Shares | 8.6k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (acquisition) | Common Shares | 1.9k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (disposition) | Common Shares | 9.6k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (acquisition) | Common Shares | 2.1k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (disposition) | Common Shares | 66k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (acquisition) | Common Shares | 1.2k | $0.00 | $0 | | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (disposition) | Common Shares | 21.9k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (acquisition) | Common Shares | 4.7k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (disposition) | Common Shares | 4.7k | $0.00 | $0 | See Footnote | 12/29/2022 |
| 12/29/2022 | Jerel Davis | Director | Other (acquisition) | Common Shares | 3k | $0.00 | $0 | | 12/29/2022 |
| 12/20/2022 | Koehler Maria | EVP, Chief Medical Officer | Exercise | Employee Stock Option (right to buy) | 48.5k | $2.06 | $99.9k | | 12/20/2022 |
| 12/20/2022 | Koehler Maria | EVP, Chief Medical Officer | Exercise | Employee Stock Option (right to buy) | 51 | $2.43 | $123.7 | | 12/20/2022 |
| 12/09/2022 | Jerel Davis | Director | Sale | Common Shares | 250k | $16.00 | $4M | See Footnote | 12/09/2022 |
| 06/13/2022 | BVF PARTNERS L P/IL | 10% Owner | Purchase | | 74.7k | $12.73 | $950.5k | | 06/13/2022 |
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