| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/07/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 2.9k | $25.39 | $74.1k | | 08/07/2023 |
| 08/01/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 1.2k | $26.26 | $32.4k | | 08/01/2023 |
| 08/01/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 4.2k | $0.00 | $0 | | 08/01/2023 |
| 03/03/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 504 | $24.29 | $12.2k | | 03/03/2023 |
| 02/14/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 273 | $28.44 | $7.8k | | 02/01/2023 |
| 02/10/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 777 | $0.00 | $0 | | 02/01/2023 |
| 02/01/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 6.9k | $0.00 | $0 | | 02/01/2023 |
| 03/01/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 2.3k | $0.00 | $0 | | 03/01/2022 |
| 03/01/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock options (right to buy) | 1.2k | $32.20 | $37.5k | | 03/01/2022 |
| 02/25/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 108 | $30.00 | $3.2k | | 02/25/2022 |
| 02/22/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 59 | $29.08 | $1.7k | | 02/22/2022 |
| 02/22/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 167 | $0.00 | $0 | | 02/22/2022 |
| 02/16/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 233 | $30.81 | $7.2k | | 02/16/2022 |
| 02/14/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 127 | $30.50 | $3.9k | | 02/14/2022 |
| 02/14/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 504 | $31.25 | $15.8k | | 02/14/2022 |
| 02/14/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 360 | $0.00 | $0 | | 02/14/2022 |
| 02/10/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 273 | $31.43 | $8.6k | | 02/10/2022 |
| 02/10/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 777 | $0.00 | $0 | | 02/10/2022 |