| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/01/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 25.1k | $0.00 | $0 | | 07/01/2023 |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 1.7k | $28.36 | $48.4k | | 06/28/2023 |
| 06/28/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Performance share units | 5.8k | $0.00 | $0 | | 06/28/2023 |
| 12/28/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 2.8k | $28.48 | $79.3k | | 12/23/2022 |
| 12/23/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 9.4k | $0.00 | $0 | | 12/23/2022 |
| 12/06/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 248 | $28.83 | $7.1k | | 12/02/2022 |
| 12/02/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 833 | $0.00 | $0 | | 12/02/2022 |
| 03/01/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 11.5k | $0.00 | $0 | | 03/01/2022 |
| 03/01/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock options (right to buy) | 41k | $32.20 | $1.3M | | 03/01/2022 |
| 02/22/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 955 | $29.08 | $27.8k | | 02/18/2022 |
| 02/18/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Performance share units | 3.3k | $0.00 | $0 | | 02/18/2022 |
| 02/10/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 758 | $31.43 | $23.8k | | 02/10/2022 |
| 02/10/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 2.2k | $0.00 | $0 | | 02/10/2022 |
| 12/02/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 248 | $35.00 | $8.7k | | 12/02/2021 |
| 12/02/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 834 | $0.00 | $0 | | 12/02/2021 |