| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 19.1k | $2.17 | $41.5k | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 18.2k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 7.1k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 27.6k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 13.2k | $2.85 | $37.7k | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 11.3k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 18.2k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 7.1k | $0.00 | $0 | | 02/28/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 248k | $3.20 | $793.6k | | 02/10/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 82.7k | $0.00 | $0 | | 02/10/2022 |