| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/12/2023 | Science 37 Holdings, Inc. | | Payment of Exercise | Common Stock | 74.8k | $0.44 | $32.9k | | 08/12/2023 |
| 08/12/2023 | Science 37 Holdings, Inc. | | Exercise | Restricted Stock Units | 256.2k | $0.00 | $0 | | 08/12/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Grant | Common Stock | 444.3k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Disposition | Stock Option | 457.5k | $9.06 | $4.1M | | 04/28/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Disposition | Stock Option | 185.9k | $11.47 | $2.1M | | 04/28/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Disposition | Stock Option | 467.4k | $10.05 | $4.7M | | 04/28/2023 |
| 08/12/2022 | Science 37 Holdings, Inc. | | Grant | Restricted Stock Units | 768.6k | $0.00 | $0 | | 08/12/2022 |
| 01/07/2022 | Science 37 Holdings, Inc. | | Grant | Stock Option | 185.9k | $11.47 | $2.1M | | 01/07/2022 |
| 10/07/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 467.4k | $10.05 | $4.7M | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Earn-Out Right | 120.6k | $0.00 | $0 | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Common Stock | 322.8k | $0.00 | $0 | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 914.9k | $0.28 | $256.2k | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 457.5k | $9.06 | $4.1M | | 10/06/2021 |