| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/12/2023 | Science 37 Holdings, Inc. | | Payment of Exercise | Common Stock | 79.8k | $0.44 | $35.1k | | 08/12/2023 |
| 08/12/2023 | Science 37 Holdings, Inc. | | Exercise | Restricted Stock Units | 230.9k | $0.00 | $0 | | 08/12/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Grant | Common Stock | 257.3k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Disposition | Stock Option | 442.8k | $10.05 | $4.4M | | 04/28/2023 |
| 04/28/2023 | Science 37 Holdings, Inc. | | Disposition | Stock Option | 200.5k | $11.47 | $2.3M | | 04/28/2023 |
| 08/12/2022 | Science 37 Holdings, Inc. | | Grant | Restricted Stock Units | 692.6k | $0.00 | $0 | | 08/12/2022 |
| 04/20/2022 | Science 37 Holdings, Inc. | | Exercise | Stock Option | 3.9k | $0.85 | $3.3k | | 04/20/2022 |
| 04/20/2022 | Science 37 Holdings, Inc. | | Exercise | Stock Option | 56.7k | $0.40 | $22.7k | | 04/20/2022 |
| 01/07/2022 | Science 37 Holdings, Inc. | | Grant | Stock Option | 200.5k | $11.47 | $2.3M | | 01/07/2022 |
| 10/07/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 442.8k | $10.05 | $4.4M | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Common Stock | 533.3k | $0.00 | $0 | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 4.5k | $0.85 | $3.9k | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 10.7k | $0.85 | $9.1k | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Stock Option | 295k | $0.40 | $118k | | 10/06/2021 |
| 10/06/2021 | Science 37 Holdings, Inc. | | Grant | Earn-Out Right | 107.7k | $0.00 | $0 | | 10/06/2021 |