| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 11.8k | $2.17 | $25.6k | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 14.8k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 5.3k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 23k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 8.3k | $2.85 | $23.5k | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 10k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 14.8k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 5.3k | $0.00 | $0 | | 02/28/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 206.7k | $3.20 | $661.3k | | 02/10/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 68.9k | $0.00 | $0 | | 02/10/2022 |