| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/03/2023 | WELCH DANIEL G | Director | Other (disposition) | Stock option (right to buy) | 411k | $2.60 | $1.1M | | 08/03/2023 |
| 08/03/2023 | LOVE TED W | Director | Grant | Stock option (right to buy) | 75k | $0.00 | $0 | | 08/03/2023 |
| 08/03/2023 | WELCH DANIEL G | Director | Other (acquisition) | Stock option (right to buy) | 205.5k | $2.60 | $534.3k | By Trust | 08/03/2023 |
| 08/03/2023 | WELCH DANIEL G | Director | Other (acquisition) | Stock option (right to buy) | 205.5k | $2.60 | $534.3k | By Trust | 08/03/2023 |
| 05/10/2023 | BVF PARTNERS L P/IL | 10% Owner | Other (disposition) | | 4M | $0.00 | $0 | | 05/10/2023 |
| 05/10/2023 | BVF PARTNERS L P/IL | 10% Owner | Other (disposition) | | 2.9M | $0.00 | $0 | | 05/10/2023 |
| 05/10/2023 | BVF PARTNERS L P/IL | 10% Owner | Other (disposition) | | 462.6k | $0.00 | $0 | | 05/10/2023 |
| 05/10/2023 | BVF PARTNERS L P/IL | 10% Owner | Other (acquisition) | | 4M | $0.00 | $0 | | 05/10/2023 |
| 05/10/2023 | BVF PARTNERS L P/IL | 10% Owner | Other (acquisition) | | 2.9M | $0.00 | $0 | | 05/10/2023 |
| 05/10/2023 | BVF PARTNERS L P/IL | 10% Owner | Other (acquisition) | | 462.6k | $0.00 | $0 | | 05/10/2023 |
| 02/07/2023 | Yoon Jun | CFO | Purchase | American Depositary Shares | 600 | $15.00 | $9k | | 02/07/2023 |
| 02/07/2023 | Bach Mark Allen | Chief Medical Officer | Purchase | American Depositary Shares | 1.5k | $15.00 | $22.5k | | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series A+ Convertible Preferred Shares | 568.1k | $0.00 | $0 | Entities managed by Impresa Management LLC whose shares are subject to reporting by the Undersigned | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series A Convertible Preferred Shares | 3.6M | $0.00 | $0 | Entities managed by Impresa Management LLC whose shares are subject to reporting by the Undersigned | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series B-1 Convertible Preferred Shares | 6.9k | $0.00 | $0 | F-Prime Capital Partners Life Sciences Advisors Fund VI LP | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series B Convertible Preferred Shares | 7.4k | $0.00 | $0 | F-Prime Capital Partners Life Sciences Advisors Fund VI LP | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series A+ Convertible Preferred Shares | 10.2k | $0.00 | $0 | F-Prime Capital Partners Life Sciences Advisors Fund VI LP | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series A Convertible Preferred Shares | 57.5k | $0.00 | $0 | F-Prime Capital Partners Life Sciences Advisors Fund VI LP | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Series A Convertible Preferred Shares | 965.1k | $0.00 | $0 | F-Prime Capital Partners Life Sciences Fund VI LP | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Ordinary Shares | 214.7k | $0.00 | $0 | Entities managed by Impresa Management LLC whose shares are subject to reporting by the Undersigned | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Ordinary Shares | 414.6k | $0.00 | $0 | Entities managed by Impresa Management LLC whose shares are subject to reporting by the Undersigned | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Ordinary Shares | 568.1k | $0.00 | $0 | Entities managed by Impresa Management LLC whose shares are subject to reporting by the Undersigned | 02/07/2023 |
| 02/07/2023 | FMR LLC | | Conversion | Ordinary Shares | 3.6M | $0.00 | $0 | Entities managed by Impresa Management LLC whose shares are subject to reporting by the Undersigned | 02/07/2023 |
| 02/07/2023 | Stevens Raymond C | CEO | Purchase | American Depositary Shares | 4k | $15.00 | $60k | See footnote | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 4M | $0.00 | $0 | Eight Roads Investments | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 620.5k | $0.00 | $0 | Eight Roads Investments | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 452.9k | $0.00 | $0 | Eight Roads Investments | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 179.2k | $0.00 | $0 | Eight Roads Investments | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 71.6k | $0.00 | $0 | ERVC Healthcare Advisors IV, LP | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 10.2k | $0.00 | $0 | ERVC Healthcare Advisors IV, LP | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 7.4k | $0.00 | $0 | ERVC Healthcare Advisors IV, LP | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 494k | $0.00 | $0 | ERVC Healthcare V, LP | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Ordinary Shares | 624.2k | $0.00 | $0 | ERVC Healthcare IV, LP | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Series A Convertible Preferred Shares | 4M | $0.00 | $0 | Eight Roads Investments | 02/07/2023 |
| 02/07/2023 | FIL Ltd | | Conversion | Series A+ Convertible Preferred Shares | 620.5k | $0.00 | $0 | Eight Roads Investments | 02/07/2023 |
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