| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/18/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Performance Stock Units | 66.4k | $0.00 | $0 | | 01/18/2023 |
| 10/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 4.6k | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 2k | $3.76 | $7.6k | | 10/13/2022 |
| 07/25/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 166k | $3.17 | $526.1k | | 07/25/2022 |
| 07/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 07/13/2022 |
| 07/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 4.6k | $0.00 | $0 | | 07/13/2022 |
| 07/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 2k | $3.01 | $6.1k | | 07/13/2022 |
| 04/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 4.6k | $0.00 | $0 | | 04/13/2022 |
| 04/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 04/13/2022 |
| 04/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 2k | $6.07 | $12.2k | | 04/13/2022 |
| 01/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 2k | $8.30 | $16.7k | | 01/13/2022 |
| 01/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 01/13/2022 |
| 01/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 4.6k | $0.00 | $0 | | 01/13/2022 |
| 10/29/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Other (acquisition) | Common Stock | 817 | $9.36 | $7.6k | | 10/29/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 433 | $10.55 | $4.6k | | 10/13/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 10/13/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Restricted Stock Units | 55.3k | $0.00 | $0 | | 10/13/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 92.2k | $10.55 | $972.7k | | 10/13/2021 |
| 07/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 433 | $13.48 | $5.8k | | 07/13/2021 |
| 07/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 07/13/2021 |
| 04/30/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Other (acquisition) | Common Stock | 971 | $13.90 | $13.5k | | 07/13/2021 |
| 04/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 433 | $16.66 | $7.2k | | 04/13/2021 |
| 04/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 04/13/2021 |
| 01/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 433 | $18.16 | $7.9k | | 01/13/2021 |
| 01/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 01/13/2021 |
| 10/30/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Other (acquisition) | Common Stock | 637 | $11.65 | $7.4k | | 10/30/2020 |
| 10/13/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 170k | $15.72 | $2.7M | | 10/13/2020 |
| 10/13/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Restricted Stock Units | 20k | $0.00 | $0 | | 10/13/2020 |
| 07/15/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 300k | $18.29 | $5.5M | | 07/15/2019 |
| 05/22/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Purchase | Common Stock | 3k | $17.55 | $52.6k | | 05/22/2019 |
| 12/15/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Stock Option (Right to Buy) | 19.5k | $24.97 | $486.9k | | 12/15/2018 |
| 12/15/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Stock Option (Right to Buy) | 30k | $24.97 | $749.1k | | 12/15/2018 |
| 11/02/2018 | SENOMYX INC | SNMX | Disposition | Stock Option (right to buy) | 417k | $1.02 | $425.3k | | 11/02/2018 |
| 11/02/2018 | SENOMYX INC | SNMX | Other | Common Stock | 108.3k | $1.50 | $162.4k | By family trust | 11/02/2018 |
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