| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/03/2023 | Mulligan Donal L | Director | Sale | Common Stock | 1.8k | $73.94 | $130.5k | | 10/03/2023 |
| 10/03/2023 | Mulligan Donal L | Director | Exercise | Stock Option (right to buy) | 1.8k | $64.20 | $113.3k | | 10/03/2023 |
| 08/14/2023 | Huml David W. | PRESIDENT AND CEO | Sale | Common Stock | 4.6k | $83.83 | $385.5k | | 08/14/2023 |
| 08/14/2023 | Huml David W. | PRESIDENT AND CEO | Exercise | Stock Option (right to buy) | 2.7k | $73.20 | $201.1k | | 08/14/2023 |
| 08/14/2023 | Huml David W. | PRESIDENT AND CEO | Exercise | Stock Option (right to buy) | 1.9k | $52.42 | $97.1k | | 08/14/2023 |
| 08/10/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Sale | Common Stock | 5.6k | $85.79 | $476.9k | | 08/10/2023 |
| 08/10/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Exercise | Stock Option (right to buy) | 4.1k | $60.67 | $246k | | 08/10/2023 |
| 05/26/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 5.6k | $73.20 | $407.6k | | 05/25/2023 |
| 05/26/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 9.1k | $67.70 | $617.9k | | 05/25/2023 |
| 05/26/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 1.3k | $66.97 | $87.3k | | 05/25/2023 |
| 05/26/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Sale | Common Stock | 16k | $75.41 | $1.2M | | 05/25/2023 |
| 05/25/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 2k | $52.42 | $103.1k | | 05/25/2023 |
| 05/25/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 2.5k | $73.20 | $181.4k | | 05/25/2023 |
| 05/25/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Sale | Common Stock | 4.4k | $75.74 | $336.7k | | 05/25/2023 |
| 05/24/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Sale | Common Stock | 5.4k | $76.14 | $413.4k | | 05/23/2023 |
| 05/24/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Sale | Common Stock | 1.5k | $76.83 | $115.2k | | 05/23/2023 |
| 05/24/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 6.9k | $52.42 | $363.3k | | 05/23/2023 |
| 05/23/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 3k | $76.25 | $227.4k | | 05/23/2023 |
| 05/23/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Exercise | Stock Option (right to buy) | 850 | $52.42 | $44.6k | | 05/23/2023 |
| 05/23/2023 | McKnight Carol E. | FORMER, SVP, CHIEF ADMIN OFFR | Sale | Common Stock | 3.8k | $77.57 | $297.3k | | 05/23/2023 |
| 05/07/2023 | West Fay | SENIOR VP, CFO | Payment of Exercise | Common Stock | 2k | $78.31 | $153.8k | | 05/07/2023 |
| 05/03/2023 | Windley David | Director | Grant | Common Stock | 1.4k | $0.00 | $0 | | 05/03/2023 |
| 05/03/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Sale | Common Stock | 3.7k | $79.46 | $295.5k | | 05/03/2023 |
| 05/03/2023 | EICHER CAROL S | Director | Grant | Common Stock | 1.4k | $0.00 | $0 | | 05/03/2023 |
| 04/03/2023 | Mulligan Donal L | Director | Sale | Common Stock | 2.3k | $68.38 | $158.6k | | 04/03/2023 |
| 04/03/2023 | Mulligan Donal L | Director | Exercise | Stock Option (right to buy) | 2.3k | $46.59 | $108.1k | | 04/03/2023 |
| 03/07/2023 | Arvani Azita | Director | Sale | Common Stock | 2.3k | $70.69 | $164k | | 03/07/2023 |
| 03/07/2023 | Arvani Azita | Director | Exercise | Stock Option (right to buy) | 2.3k | $46.59 | $108.1k | | 03/07/2023 |
| 02/28/2023 | West Fay | SENIOR VP, CFO | Grant | Common Stock | 3.1k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | West Fay | SENIOR VP, CFO | Grant | Employee Stock Option (right to buy) | 9.3k | $72.88 | $677.1k | | 02/28/2023 |
| 02/28/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Grant | Common Stock | 3.9k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Payment of Exercise | Common Stock | 1.1k | $72.88 | $78.4k | | 02/28/2023 |
| 02/28/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Grant | Common Stock | 2.7k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Zay Richard H. | CHIEF COMMERCIAL OFFICER | Grant | Employee Stock Option (right to buy) | 8.3k | $72.88 | $601.8k | | 02/28/2023 |
| 02/28/2023 | Huml David W. | PRESIDENT AND CEO | Grant | Common Stock | 3.6k | $0.00 | $0 | | 02/28/2023 |
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