| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/15/2017 | Singer Robert S | Director | Disposition | Common Stock | 9.7k | $90.00 | $869.5k | | 06/15/2017 |
| 06/15/2017 | Singer Robert S | Director | Disposition | Restricted Stock Units | 1.7k | $90.00 | $153.8k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Stock Option (Right to Buy) | 11.5k | $78.26 | $900.9k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Stock Option (Right to Buy) | 12.9k | $74.65 | $961k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Stock Option (Right to Buy) | 10.5k | $81.55 | $858.9k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Stock Option (Right to Buy) | 17.7k | $73.76 | $1.3M | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Stock Option (Right to Buy) | 15k | $73.76 | $1.1M | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Grant | Performance Shares | 1.1k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Performance Shares | 1.9k | $90.00 | $172.4k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Grant | Performance Shares | 3.6k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Performance Shares | 4.9k | $90.00 | $439.1k | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Common Stock | 1k | $90.00 | $93.1k | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Restricted Stock Units | 1.5k | $90.00 | $138.6k | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Restricted Stock Units | 1.1k | $90.00 | $101.5k | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Restricted Stock Units | 2.6k | $90.00 | $235.1k | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Restricted Stock Units | 4.4k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Restricted Stock Units | 6.6k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Stock Option (Right to Buy) | 17.7k | $73.76 | $1.3M | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Stock Option (Right to Buy) | 29.5k | $73.76 | $2.2M | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Grant | Performance Shares | 752 | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Performance Shares | 1.3k | $90.00 | $118.1k | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Grant | Performance Shares | 3.6k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Ormesher Ian Eric | SVP, Global Human Resources | Disposition | Performance Shares | 4.9k | $90.00 | $439.1k | | 06/15/2017 |
| 06/15/2017 | BERNICK HOWARD B | Director | Disposition | Common Stock | 22.4k | $90.00 | $2M | By sole member LLC | 06/15/2017 |
| 06/15/2017 | BERNICK HOWARD B | Director | Disposition | Restricted Stock Units | 1.7k | $90.00 | $153.8k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Common Stock | 3.5k | $90.00 | $316.4k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Common Stock | 17.5k | $90.00 | $1.6M | Trust Account | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Restricted Stock Units | 2.1k | $90.00 | $185.7k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Restricted Stock Units | 1.6k | $90.00 | $148.2k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Restricted Stock Units | 2.6k | $90.00 | $235.1k | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Restricted Stock Units | 4.4k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Restricted Stock Units | 6.6k | $0.00 | $0 | | 06/15/2017 |
| 06/15/2017 | Hondmann Dirk | SVP & Chief Scientific Officer | Disposition | Stock Option (Right to Buy) | 5.3k | $58.86 | $309.9k | | 06/15/2017 |
| 06/15/2017 | Jakobsen Peter Kasper | President and CEO | Disposition | Stock Option (Right to Buy) | 23.5k | $58.86 | $1.4M | | 06/15/2017 |
| 06/15/2017 | Jakobsen Peter Kasper | President and CEO | Disposition | Stock Option (Right to Buy) | 24.6k | $78.26 | $1.9M | | 06/15/2017 |
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