| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/01/2017 | White Marvin L | Director | Disposition | Stock Option (Right to Buy) | 1.6k | $9.62 | $15.7k | | 03/01/2017 |
| 03/01/2017 | White Marvin L | Director | Disposition | Stock Option (Right to Buy) | 453 | $36.20 | $16.4k | | 03/01/2017 |
| 03/01/2017 | Skwierczynski Raymond | Head,Pharmaceutical Operations | Other | Common Stock | 3.6k | $46.50 | $168.1k | | 03/01/2017 |
| 03/01/2017 | Skwierczynski Raymond | Head,Pharmaceutical Operations | Disposition | Employee Stock Option (Right to Buy) | 90k | $5.69 | $512.1k | | 03/01/2017 |
| 03/01/2017 | Skwierczynski Raymond | Head,Pharmaceutical Operations | Disposition | Employee Stock Option (Right to Buy) | 15k | $6.75 | $101.2k | | 03/01/2017 |
| 03/01/2017 | Marengere Luc | 10% Owner | Other | Common Stock | 1.5M | $46.50 | $71.9M | By TVM Life Science Ventures VII L.P. | 03/01/2017 |
| 03/01/2017 | Marengere Luc | 10% Owner | Disposition | Stock Option (Right to Buy) | 6k | $10.00 | $59.5k | | 03/01/2017 |
| 03/01/2017 | Marengere Luc | 10% Owner | Disposition | Stock Option (Right to Buy) | 1.4k | $8.50 | $12.3k | | 03/01/2017 |
| 03/01/2017 | Marengere Luc | 10% Owner | Disposition | Stock Option (Right to Buy) | 8.9k | $6.24 | $55.5k | | 03/01/2017 |
| 03/01/2017 | Marengere Luc | 10% Owner | Disposition | Stock Option (Right to Buy) | 2.4k | $9.62 | $22.8k | | 03/01/2017 |
| 03/01/2017 | Marengere Luc | 10% Owner | Disposition | Stock Option (Right to Buy) | 658 | $36.20 | $23.8k | | 03/01/2017 |
| 03/01/2017 | Kuca Bernice | Head,Clin. and Reg. Operations | Other | Common Stock | 2.7k | $46.50 | $126.9k | | 03/01/2017 |
| 03/01/2017 | Kuca Bernice | Head,Clin. and Reg. Operations | Disposition | Common Stock | 37.5k | $46.50 | $1.7M | | 03/01/2017 |
| 03/01/2017 | Kuca Bernice | Head,Clin. and Reg. Operations | Disposition | Employee Stock Option (right to buy) | 270.4k | $10.00 | $2.7M | | 03/01/2017 |
| 03/01/2017 | Kuca Bernice | Head,Clin. and Reg. Operations | Disposition | Employee Stock Option (right to buy) | 37.5k | $6.75 | $253.1k | | 03/01/2017 |
| 03/01/2017 | White Marvin L | Director | Disposition | Stock Option (Right to Buy) | 6.6k | $8.60 | $56.6k | | 03/01/2017 |
| 03/01/2017 | White Marvin L | Director | Disposition | Stock Option (Right to Buy) | 997 | $8.50 | $8.5k | | 03/01/2017 |
| 03/01/2017 | White Marvin L | Director | Disposition | Stock Option (Right to Buy) | 8.9k | $6.24 | $55.5k | | 03/01/2017 |
| 03/01/2017 | PAPPAS ARTHUR M | 10% Owner | Other | Common Stock | 1.9M | $46.50 | $87M | By A. M. Pappas Life Science Ventures III, L.P. | 03/01/2017 |
| 03/01/2017 | PAPPAS ARTHUR M | 10% Owner | Other | Common Stock | 116.3k | $46.50 | $5.4M | By PV III CEO Fund, L.P. | 03/01/2017 |
| 03/01/2017 | PAPPAS ARTHUR M | 10% Owner | Other | Common Stock | 5.5k | $46.50 | $257.1k | By Pappas Capital, LLC | 03/01/2017 |
| 03/01/2017 | PAPPAS ARTHUR M | 10% Owner | Disposition | Stock Option (Right to Buy) | 6k | $10.00 | $59.5k | | 03/01/2017 |
| 03/01/2017 | PAPPAS ARTHUR M | 10% Owner | Disposition | Stock Option (Right to Buy) | 8.9k | $6.24 | $55.5k | | 03/01/2017 |
| 03/01/2017 | Lawton Alison Frances | Director | Disposition | Stock Option (Right to Buy) | 1.4k | $6.54 | $9.3k | | 03/01/2017 |
| 03/01/2017 | Lawton Alison Frances | Director | Disposition | Stock Option (Right to Buy) | 8.9k | $6.24 | $55.5k | | 03/01/2017 |
| 03/01/2017 | Lawton Alison Frances | Director | Disposition | Stock Option (Right to Buy) | 658 | $36.20 | $23.8k | | 03/01/2017 |
| 03/01/2017 | Mathers Thomas P. | CEO | Other | Common Stock | 173.5k | $46.50 | $8.1M | | 03/01/2017 |
| 03/01/2017 | Mathers Thomas P. | CEO | Disposition | Common Stock | 83k | $46.50 | $3.9M | | 03/01/2017 |
| 03/01/2017 | Mathers Thomas P. | CEO | Disposition | Employee Stock Option (Right to Buy) | 360.5k | $10.00 | $3.6M | | 03/01/2017 |
| 03/01/2017 | Mathers Thomas P. | CEO | Disposition | Employee Stock Option (Right to Buy) | 83k | $6.75 | $560.2k | | 03/01/2017 |
| 03/01/2017 | Mathers Thomas P. | CEO | Disposition | Restricted Stock Units | 105.1k | $46.50 | $4.9M | | 03/01/2017 |
| 03/01/2017 | CORRIGAN MARK | Director | Disposition | Stock Option (Right to Buy) | 8.1k | $3.79 | $30.8k | | 03/01/2017 |
| 03/01/2017 | Hogan Linda C. | Head, Bus. Dev. and Strategy | Disposition | Stock Option (Right to Buy) | 47k | $10.00 | $469.7k | | 03/01/2017 |
| 03/01/2017 | Hogan Linda C. | Head, Bus. Dev. and Strategy | Disposition | Stock Option (Right to Buy) | 5.7k | $7.56 | $43.4k | | 03/01/2017 |
| 03/01/2017 | Hogan Linda C. | Head, Bus. Dev. and Strategy | Disposition | Stock Option (Right to Buy) | 26.6k | $6.75 | $179.5k | | 03/01/2017 |
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