| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/22/2023 | Demopulos Gregory A MD | Chairman, CEO & President | Grant | Stock Option (right to buy) | 715k | $2.94 | $2.1M | | 09/22/2023 |
| 09/22/2023 | JACOBSEN MICHAEL A | VP, Finance & CAO | Grant | Stock Option (right to buy) | 100k | $2.94 | $294k | | 09/22/2023 |
| 09/22/2023 | Cancelmo Peter B | VP, General Counsel | Grant | Stock Option (right to buy) | 100k | $2.94 | $294k | | 09/22/2023 |
| 05/22/2023 | HANISH ARNOLD C | Director | Sale | Common Stock | 5k | $6.46 | $32.3k | | 05/22/2023 |
| 05/22/2023 | HANISH ARNOLD C | Director | Exercise | Stock Option (Right to Buy) | 5k | $5.30 | $26.5k | | 05/22/2023 |
| 05/22/2023 | Cable Thomas J. | Director | Sale | Common Stock | 5k | $6.53 | $32.6k | | 05/22/2023 |
| 05/22/2023 | Cable Thomas J. | Director | Exercise | Stock Option (Right to Buy) | 5k | $5.30 | $26.5k | | 05/22/2023 |
| 05/12/2023 | Perkinson Diana T. | Director | Grant | Stock Option (Right to Buy) | 30k | $5.71 | $171.3k | | 05/12/2023 |
| 09/21/2022 | HANISH ARNOLD C | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 09/21/2022 | Zumwalt Kurt | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 09/21/2022 | Cable Thomas J. | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 09/21/2022 | Demopulos Gregory A MD | Chairman, CEO & President | Grant | Stock Option (right to buy) | 650k | $3.93 | $2.6M | | 09/21/2022 |
| 09/21/2022 | JACOBSEN MICHAEL A | VP, Finance & CAO | Grant | Stock Option (right to buy) | 85k | $3.93 | $334k | | 09/21/2022 |
| 09/21/2022 | Hood Leroy E. MD PhD | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 09/21/2022 | Cancelmo Peter B | VP, General Counsel | Grant | Stock Option (right to buy) | 80k | $3.93 | $314.4k | | 09/21/2022 |
| 09/21/2022 | Shah Rajiv | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 09/21/2022 | Bumol Thomas F. | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 09/21/2022 | Demopulos Peter A MD | Director | Grant | Stock Option (Right to Buy) | 7.5k | $3.93 | $29.5k | | 09/21/2022 |
| 06/17/2022 | Shah Rajiv | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 06/17/2022 | Zumwalt Kurt | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 06/17/2022 | HANISH ARNOLD C | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 06/17/2022 | Hood Leroy E. MD PhD | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 06/17/2022 | Demopulos Peter A MD | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 06/17/2022 | Cable Thomas J. | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 06/17/2022 | Bumol Thomas F. | Director | Grant | | 7.5k | $2.00 | $15k | | 06/17/2022 |
| 09/08/2021 | HANISH ARNOLD C | Director | Exercise | Common Stock | 10k | $9.44 | $94.4k | See footnote | 09/08/2021 |
| 09/08/2021 | HANISH ARNOLD C | Director | Exercise | Stock Option (Right to Buy) | 10k | $9.44 | $94.4k | | 09/08/2021 |
| 07/02/2021 | Demopulos Gregory A MD | Chairman, CEO & President | Grant | Stock Option (right to buy) | 550k | $14.99 | $8.2M | | 07/02/2021 |
| 07/02/2021 | Cancelmo Peter B | VP, General Counsel | Grant | Stock Option (right to buy) | 75k | $14.99 | $1.1M | | 07/02/2021 |
| 07/02/2021 | JACOBSEN MICHAEL A | VP, Finance & CAO | Grant | Stock Option (right to buy) | 75k | $14.99 | $1.1M | | 07/02/2021 |
| 06/17/2021 | Demopulos Gregory A MD | Chairman, CEO & President | Sale | Common Stock | 36.9k | $14.90 | $549.2k | | 06/15/2021 |
| 06/17/2021 | Demopulos Gregory A MD | Chairman, CEO & President | Exercise | Stock Option (right to buy) | 36.9k | $4.10 | $151.1k | | 06/15/2021 |
| 06/15/2021 | Demopulos Gregory A MD | Chairman, CEO & President | Exercise | Stock Option (right to buy) | 36.9k | $4.10 | $151.1k | | 06/15/2021 |
| 06/15/2021 | Demopulos Gregory A MD | Chairman, CEO & President | Sale | Common Stock | 36.9k | $15.02 | $553.6k | | 06/15/2021 |
| 06/11/2021 | Bumol Thomas F. | Director | Grant | | 7.5k | $15.81 | $118.6k | | 06/11/2021 |
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