| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/15/2023 | Beeson Jonn R. | Director | Grant | Stock Option (right to buy) | 28.2k | $1.20 | $33.9k | | 08/15/2023 |
| 08/15/2023 | Beeson Jonn R. | Director | Grant | Common Stock | 145.2k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Schallenberger Mark A. | Chief Operations Officer | Grant | Stock Option (right to buy) | 135.5k | $1.20 | $162.6k | | 08/15/2023 |
| 08/15/2023 | Schallenberger Mark A. | Chief Operations Officer | Grant | Common Stock | 116.1k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Brandt Kevin D | Chief Commercial Officer | Grant | Common Stock | 120.5k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Brandt Kevin D | Chief Commercial Officer | Payment of Exercise | Common Stock | 49.9k | $1.18 | $58.9k | | 08/15/2023 |
| 08/15/2023 | Browne Sean E | President and CEO | Grant | Common Stock | 174.2k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Browne Sean E | President and CEO | Grant | Stock Option (right to buy) | 203.3k | $1.20 | $243.9k | | 08/15/2023 |
| 08/15/2023 | Neils Scott C | CFO | Grant | Common Stock | 116.1k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Neils Scott C | CFO | Payment of Exercise | Common Stock | 25.2k | $1.18 | $29.8k | | 08/15/2023 |
| 08/15/2023 | Neils Scott C | CFO | Grant | Stock Option (right to buy) | 135.5k | $1.20 | $162.6k | | 08/15/2023 |
| 08/15/2023 | Brandt Kevin D | Chief Commercial Officer | Grant | Stock Option (right to buy) | 140.6k | $1.20 | $168.7k | | 08/15/2023 |
| 08/15/2023 | BAKEWELL JOHN K | Director | Grant | Common Stock | 145.2k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | BAKEWELL JOHN K | Director | Grant | Stock Option (right to buy) | 28.2k | $1.20 | $33.9k | | 08/15/2023 |
| 08/15/2023 | McNamara Robert | Director | Grant | Common Stock | 145.2k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | McNamara Robert | Director | Grant | Stock Option (right to buy) | 28.2k | $1.20 | $33.9k | | 08/15/2023 |
| 08/15/2023 | Vizirgianakis Stavros G. | Director | Grant | Common Stock | 217.8k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Vizirgianakis Stavros G. | Director | Grant | Stock Option (right to buy) | 42.3k | $1.20 | $50.8k | | 08/15/2023 |
| 08/15/2023 | MITCHELL-KELLER LORI D | Director | Grant | Common Stock | 145.2k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | MITCHELL-KELLER LORI D | Director | Grant | Stock Option (right to buy) | 28.2k | $1.20 | $33.9k | | 08/15/2023 |
| 05/15/2023 | Beeson Jonn R. | Director | Grant | Common Stock | 52k | $0.00 | $0 | | 05/15/2023 |
| 11/15/2022 | Vizirgianakis Stavros G. | Director | Grant | Common Stock, $0.000001 par value | 144.6k | $0.00 | $0 | | 11/15/2022 |
| 10/07/2022 | Vizirgianakis Stavros G. | Director | Purchase | Common Stock, $0.000001 par value | 2.3M | $0.48 | $1.1M | | 10/07/2022 |
| 10/07/2022 | Vizirgianakis Stavros G. | Director | Purchase | | 566.2k | $0.48 | $271.8k | | 10/07/2022 |
| 08/25/2022 | Vizirgianakis Stavros G. | Director | Grant | Common Stock, $0.000001 par value | 70.8k | $0.00 | $0 | | 08/25/2022 |
| 08/17/2022 | Brandt Kevin D | Chief Commercial Officer | Sale | Common Stock, $0.000001 par value | 4.3k | $0.48 | $2k | | 08/15/2022 |
| 08/17/2022 | Neils Scott C | CFO | Sale | Common Stock, $0.000001 par value | 1.3k | $0.48 | $605 | | 08/15/2022 |
| 08/16/2022 | Neils Scott C | CFO | Sale | Common Stock, $0.000001 par value | 5.1k | $0.48 | $2.5k | | 08/15/2022 |
| 08/16/2022 | Brandt Kevin D | Chief Commercial Officer | Sale | Common Stock, $0.000001 par value | 18.7k | $0.49 | $9.2k | | 08/15/2022 |
| 08/15/2022 | Rizzo Matthew | 10% Owner | Grant | Common Stock, $0.000001 par value | 215.4k | $0.00 | $0 | | 08/15/2022 |
| 08/15/2022 | Eggenberg Michael | 10% Owner | Grant | Common Stock, $0.000001 par value | 215.4k | $0.00 | $0 | | 08/15/2022 |
| 08/15/2022 | Neils Scott C | CFO | Grant | Common Stock, $0.000001 par value | 251.9k | $0.00 | $0 | | 08/15/2022 |
| 08/15/2022 | Brandt Kevin D | Chief Commercial Officer | Grant | Common Stock, $0.000001 par value | 410.1k | $0.00 | $0 | | 08/15/2022 |
| 08/15/2022 | ORBIMED ADVISORS LLC | 10% Owner | Other (acquisition) | Common Stock, $0.000001 par value | 215.4k | $0.00 | $0 | See Footnotes | 08/15/2022 |
| 08/15/2022 | BAKEWELL JOHN K | Director | Grant | Common Stock, $0.000001 par value | 215.4k | $0.00 | $0 | | 08/15/2022 |
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