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Security holder agreements
| Type | Name | Date |
| Indenture | Second Supplemental Indenture, by and among Protalix BioTherapeutics, Inc., the guarantors party hereto and The Bank of New York Mellon Trust Company, N.A., as trustee, registrar, paying agent and conversion agent | 12/01/2017 |
| Indenture | Indenture, between Protalix BioTherapeutics, Inc., the guarantors party thereto, The Bank of New York Mellon Trust Company, N.A., as trustee and Wilmington Savings Fund Society, FSB, as collateral agent | 12/07/2016 |
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