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FIRST TRUST ADVISORS LP
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,160,576 | 322,959 | 61,187,512,000 | 18,977,450,000 | $28,320.00 |
| 03/31/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,837,617 | -148,548 | 42,210,062,000 | 42,153,893,000 | $22,970.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,986,165 | 256,511 | 56,169,000 | 17,823,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,729,654 | 116,225 | 38,346,000 | -8,621,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,613,429 | 344,959 | 46,967,000 | 5,272,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,268,470 | 167,687 | 41,695,000 | -9,106,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,100,783 | -395,313 | 50,801,000 | -31,649,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,496,096 | -63,405 | 82,450,000 | 1,917,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,559,501 | -262,880 | 80,533,000 | 1,569,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,822,381 | 16,839 | 78,964,000 | 15,770,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,805,542 | 215,151 | 63,194,000 | -21,860,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,590,391 | 337,397 | 85,054,000 | 40,598,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,252,994 | -280,755 | 44,456,000 | -28,781,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,533,749 | 238,728 | 73,237,000 | 31,278,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,295,021 | -495,105 | 41,959,000 | -47,332,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,790,126 | 15,968 | 89,291,000 | -30,358,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,774,158 | 423,931 | 119,649,000 | 57,390,000 | $67.44 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,350,227 | 188,217 | 62,259,000 | -27,355,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,162,010 | 430,216 | 89,614,000 | 27,975,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 731,794 | 56,038 | 61,639,000 | 6,376,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 675,756 | -137,891 | 55,263,000 | 8,747,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 813,647 | 169,331 | 46,516,000 | 3,508,000 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 644,316 | -329,554 | 43,008,000 | -7,098,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 973,870 | 334,291 | 50,106,000 | 12,755,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 639,579 | 96,712 | 37,351,000 | 14,697,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 542,867 | -107,465 | 22,654,000 | -11,697,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 650,332 | 59,261 | 34,351,000 | 9,588,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 591,071 | -872,875 | 24,763,000 | -70,276,000 | $41.90 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 602,817 | -861,129 | 24,474,000 | -70,565,000 | $40.60 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,463,946 | 1,463,946 | 95,039,000 | 95,039,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,623,430 | 1,623,430 | 114,598,000 | 114,598,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,079,286 | 1,079,286 | 119,952,000 | 119,952,000 | $111.14 |
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