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FMR LLC
> BPMC
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Blueprint Medicines Corp | BPMC | 6,708,137 | -2,113,985 | 423,954,258,000 | 27,046,989,000 | $63,200.00 |
| 03/31/2023 | Blueprint Medicines Corp | BPMC | 8,822,122 | -135,804 | 396,907,269,000 | 396,317,031,000 | $44,990.00 |
| 09/30/2022 | Blueprint Medicines Corp | BPMC | 8,957,926 | 381,847 | 590,238,000 | 157,060,000 | $65.89 |
| 06/30/2022 | Blueprint Medicines Corp | BPMC | 8,576,079 | 3,242,698 | 433,178,000 | 92,482,000 | $50.51 |
| 03/31/2022 | Blueprint Medicines Corp | BPMC | 5,333,381 | 2,984,929 | 340,696,000 | 89,154,000 | $63.88 |
| 12/31/2021 | Blueprint Medicines Corp | BPMC | 2,348,452 | -863,512 | 251,542,000 | -78,680,000 | $107.11 |
| 09/30/2021 | Blueprint Medicines Corp | BPMC | 3,211,964 | -1,038,167 | 330,222,000 | -43,619,000 | $102.81 |
| 06/30/2021 | Blueprint Medicines Corp | BPMC | 4,250,131 | -23,485 | 373,841,000 | -41,683,000 | $87.96 |
| 03/31/2021 | Blueprint Medicines Corp | BPMC | 4,273,616 | 83,241 | 415,524,000 | -54,427,000 | $97.23 |
| 02/08/2021 | Blueprint Medicines Corp | BPMC | 4,190,375 | 0 | 441,875,044 | -28,075,956 | $105.45 |
| 12/31/2020 | Blueprint Medicines Corp | BPMC | 4,190,375 | 361,526 | 469,951,000 | 115,016,000 | $112.15 |
| 09/30/2020 | Blueprint Medicines Corp | BPMC | 3,828,849 | 68,308 | 354,935,000 | 61,613,000 | $92.70 |
| 06/30/2020 | Blueprint Medicines Corp | BPMC | 3,760,541 | -1,347,178 | 293,322,000 | -5,378,000 | $78.00 |
| 03/31/2020 | Blueprint Medicines Corp | BPMC | 5,107,719 | -2,271,471 | 298,700,000 | -292,447,000 | $58.48 |
| 12/31/2019 | Blueprint Medicines Corp | BPMC | 7,379,190 | 23,267 | 591,147,000 | 50,708,000 | $80.11 |
| 09/30/2019 | Blueprint Medicines Corp | BPMC | 7,355,923 | 210,685 | 540,439,000 | -133,571,000 | $73.47 |
| 06/30/2019 | Blueprint Medicines Corp | BPMC | 7,145,238 | 205,944 | 674,010,000 | 118,519,000 | $94.33 |
| 03/31/2019 | Blueprint Medicines Corp | BPMC | 6,939,294 | 346,738 | 555,491,000 | 200,086,000 | $80.05 |
| 02/13/2019 | Blueprint Medicines Corp | BPMC | 6,592,556 | 9,397 | 490,090,613 | -23,790,387 | $74.34 |
| 12/31/2018 | Blueprint Medicines Corp | BPMC | 6,592,556 | 9,397 | 355,405,000 | -158,476,000 | $53.91 |
| 09/30/2018 | Blueprint Medicines Corp | BPMC | 6,583,159 | 7,559 | 513,881,000 | 96,462,000 | $78.06 |
| 06/30/2018 | Blueprint Medicines Corp | BPMC | 6,575,600 | 44,401 | 417,419,000 | -181,492,000 | $63.48 |
| 03/31/2018 | Blueprint Medicines Corp | BPMC | 6,531,199 | 100,240 | 598,911,000 | 113,953,000 | $91.70 |
| 12/31/2017 | Blueprint Medicines Corp | BPMC | 6,430,959 | 564,056 | 484,958,000 | 76,210,000 | $75.41 |
| 09/30/2017 | Blueprint Medicines Corp | BPMC | 5,866,903 | 566,314 | 408,748,000 | 408,479,419 | $69.67 |
| 06/30/2017 | Blueprint Medicines Corp | BPMC | 5,300,589 | 516,835 | 268,581 | -191,033,419 | $0.05 |
| 03/31/2017 | Blueprint Medicines Corp | BPMC | 4,783,754 | 905,614 | 191,302,000 | 82,520,000 | $39.99 |
| 02/14/2017 | Blueprint Medicines Corp | BPMC | 3,878,140 | 0 | 133,214,101 | 24,432,101 | $34.35 |
| 12/31/2016 | Blueprint Medicines Corp | BPMC | 3,878,140 | -51,322 | 108,782,000 | -7,923,000 | $28.05 |
| 09/30/2016 | Blueprint Medicines Corp | BPMC | 3,929,462 | 3,929,462 | 116,705,000 | 116,705,000 | $29.70 |
| 06/30/2016 | Blueprint Medicines Corp | BPMC | 4,085,600 | 15,615 | 82,733,000 | 9,270,000 | $20.25 |
| 03/31/2016 | Blueprint Medicines Corp | BPMC | 4,069,985 | 553,512 | 73,463,000 | -19,161,000 | $18.05 |
| 12/31/2015 | Blueprint Medicines Corp | BPMC | 3,516,473 | -550,345 | 92,624,000 | 5,838,000 | $26.34 |
| 09/30/2015 | Blueprint Medicines Corp | BPMC | 4,066,818 | 108 | 86,786,000 | -20,941,000 | $21.34 |
| 06/30/2015 | Blueprint Medicines Corp | BPMC | 4,066,710 | 4,066,710 | 107,727,000 | 107,727,000 | $26.49 |
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