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FMR LLC
> LXRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | 8,511,068 | 3,270,821 | 19,490,346,000 | 6,756,546,000 | $2,290.00 |
| 03/31/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | 5,240,247 | -42,752 | 12,733,800,000 | 12,721,121,000 | $2,430.00 |
| 09/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 5,282,999 | -7,615 | 12,679,000 | 2,839,000 | $2.40 |
| 06/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 5,290,614 | 65 | 9,840,000 | -1,217,000 | $1.86 |
| 03/31/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 5,290,549 | -377,589 | 11,057,000 | -11,276,000 | $2.09 |
| 12/31/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 5,668,138 | -793,218 | 22,333,000 | -8,746,000 | $3.94 |
| 09/30/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 6,461,356 | -975,157 | 31,079,000 | -3,054,000 | $4.81 |
| 06/30/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 7,436,513 | -1,666,325 | 34,133,000 | -19,301,000 | $4.59 |
| 03/31/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 9,102,838 | 804,738 | 53,434,000 | 25,055,000 | $5.87 |
| 01/11/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 8,298,100 | -987,874 | 32,362,590 | 18,990,590 | $3.90 |
| 12/31/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 8,298,100 | -987,874 | 28,379,000 | 15,007,000 | $3.42 |
| 09/30/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 9,285,974 | -1,733,300 | 13,372,000 | -8,611,000 | $1.44 |
| 06/30/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 11,019,274 | -1,302,320 | 21,983,000 | -2,044,000 | $1.99 |
| 03/31/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 12,321,594 | -237,900 | 24,027,000 | -28,095,000 | $1.95 |
| 12/31/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 12,559,494 | -525,400 | 52,122,000 | 12,736,000 | $4.15 |
| 09/30/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 13,084,894 | -403,200 | 39,386,000 | -45,454,000 | $3.01 |
| 06/30/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 13,488,094 | -890,820 | 84,840,000 | 4,893,000 | $6.29 |
| 03/31/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 14,378,914 | -360,700 | 79,947,000 | -17,924,000 | $5.56 |
| 02/13/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 14,739,614 | -764,366 | 75,466,824 | -89,960,176 | $5.12 |
| 12/31/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 14,739,614 | -764,366 | 97,871,000 | -67,556,000 | $6.64 |
| 09/30/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,503,980 | -370,800 | 165,427,000 | -25,070,000 | $10.67 |
| 06/30/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,874,780 | 36,006 | 190,497,000 | 54,759,000 | $12.00 |
| 03/31/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,838,774 | 605 | 135,738,000 | -20,743,000 | $8.57 |
| 12/31/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,838,169 | 953 | 156,481,000 | -38,158,000 | $9.88 |
| 09/30/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,837,216 | 51,936 | 194,639,000 | 194,379,332 | $12.29 |
| 06/30/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,785,280 | 137,421 | 259,668 | -224,130,332 | $0.02 |
| 03/31/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,647,859 | 42,408 | 224,390,000 | 8,567,000 | $14.34 |
| 12/31/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,605,451 | 25,595 | 215,823,000 | -65,705,000 | $13.83 |
| 09/30/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,579,856 | 15,579,856 | 281,528,000 | 281,528,000 | $18.07 |
| 06/30/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,573,212 | 7,764 | 223,476,000 | 37,469,000 | $14.35 |
| 03/31/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,565,448 | 22,035 | 186,007,000 | -20,876,000 | $11.95 |
| 12/31/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,543,413 | 1,452 | 206,883,000 | 39,962,000 | $13.31 |
| 09/30/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 15,541,961 | 626,869 | 166,921,000 | 46,855,000 | $10.74 |
| 06/30/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 14,915,092 | 14,915,092 | 120,066,000 | 120,066,000 | $8.05 |
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