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Natixis Investment Managers International
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 88,235 | -37,890 | 31,050,779,000 | 31,014,261,000 | $351,910.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 126,125 | -97,650 | 36,518,000 | -26,539,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 223,775 | -4,830 | 63,057,000 | 3,398,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 228,605 | -26,125 | 59,659,000 | 3,721,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 254,730 | 254,730 | 55,938,000 | 55,938,000 | $219.60 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -7,409 | 0 | -1,428,000 | |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,409 | 2,153 | 1,428,000 | 534,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,256 | -4,133 | 894,000 | -635,000 | $170.09 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,389 | 9,389 | 1,529,000 | 1,529,000 | $162.85 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -5,142 | 0 | -782,000 | |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,142 | 5,142 | 782,000 | 782,000 | $152.08 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -3,784 | 0 | -394,000 | |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -3,784 | 0 | -394,000 | |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,784 | 3,784 | 394,000 | 394,000 | $104.12 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,310 | 3,310 | 409,000 | 409,000 | $123.56 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,337 | 2,337 | 276,000 | 276,000 | $118.10 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,403 | 1,403 | 167,000 | 167,000 | $119.03 |
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