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PERCEPTIVE ADVISORS LLC
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Xenon Pharmaceuticals Inc. | XENE | 1,223,377 | -697,896 | 47,100,015,000 | -28,655,779,000 | $38,500.00 |
| 12/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 1,921,273 | -201,262 | 75,755,794,000 | 75,679,170,000 | $39,430.00 |
| 09/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 2,122,535 | 0 | 76,624,000 | 12,056,000 | $36.10 |
| 06/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 2,122,535 | -288,912 | 64,568,000 | -9,150,000 | $30.42 |
| 03/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 2,411,447 | 0 | 73,718,000 | -1,616,000 | $30.57 |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 2,411,447 | 389,396 | 75,334,000 | 44,437,000 | $31.24 |
| 09/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 2,022,051 | 343,078 | 30,897,000 | -365,000 | $15.28 |
| 06/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 1,678,973 | 1,163,931 | 31,262,000 | 22,043,000 | $18.62 |
| 03/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 515,042 | 515,042 | 9,219,000 | 9,219,000 | $17.90 |
| 09/30/2017 | Xenon Pharmaceuticals Inc. | XENE | 0 | -723,853 | 0 | -2,280,000 | |
| 06/30/2017 | Xenon Pharmaceuticals Inc. | XENE | 723,853 | 0 | 2,280,000 | -615,000 | $3.15 |
| 03/31/2017 | Xenon Pharmaceuticals Inc. | XENE | 723,853 | -16,419 | 2,895,000 | 2,889,300 | $4.00 |
| 12/31/2016 | Xenon Pharmaceuticals Inc. | XENE | 740,272 | -22,528 | 5,700 | -6,173,300 | $0.01 |
| 09/30/2016 | Xenon Pharmaceuticals Inc. | XENE | 762,800 | 330,000 | 6,179,000 | 3,626,000 | $8.10 |
| 06/30/2016 | Xenon Pharmaceuticals Inc. | XENE | 432,800 | 432,800 | 2,553,000 | 2,553,000 | $5.90 |
| 03/31/2016 | Xenon Pharmaceuticals Inc. | XENE | 205,800 | 205,800 | 1,438,000 | 1,438,000 | $6.99 |
| 12/31/2015 | Xenon Pharmaceuticals Inc. | XENE | 205,800 | 0 | 1,655,000 | -44,000 | $8.04 |
| 09/30/2015 | Xenon Pharmaceuticals Inc. | XENE | 205,800 | 205,800 | 1,699,000 | 1,699,000 | $8.26 |
| 06/30/2015 | Xenon Pharmaceuticals Inc. | XENE | 225,000 | 225,000 | 2,594,000 | 2,594,000 | $11.53 |
| 03/31/2015 | Xenon Pharmaceuticals Inc. | XENE | 225,000 | 225,000 | 3,795,000 | 3,795,000 | $16.87 |
| 12/31/2014 | Xenon Pharmaceuticals Inc. | XENE | 225,000 | 225,000 | 4,444,000 | 4,444,000 | $19.75 |
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