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ArrowMark Colorado Holdings LLC
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,573,254 | 132,268 | 44,554,553,000 | 4,091,666,000 | $28,320.00 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,440,986 | 60,597 | 40,462,887,000 | 40,423,850,000 | $28,080.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,380,389 | 2,609 | 39,037,000 | 8,492,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,377,780 | 81,832 | 30,545,000 | -7,180,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,295,948 | -16,216 | 37,725,000 | -5,406,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,312,164 | 231,855 | 43,131,000 | -6,725,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,080,309 | 46,878 | 49,856,000 | -7,096,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,033,431 | -86,135 | 56,952,000 | -862,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,119,566 | -48,369 | 57,814,000 | 7,207,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,167,935 | 86,111 | 50,607,000 | 12,743,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,081,824 | 970 | 37,864,000 | -19,940,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,080,854 | -27,387 | 57,804,000 | 18,484,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,108,241 | -160 | 39,320,000 | -13,606,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,108,401 | 69,326 | 52,926,000 | 19,260,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,039,075 | 217,359 | 33,666,000 | -7,321,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 821,716 | 83,820 | 40,987,000 | -8,777,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 737,896 | 56,093 | 49,764,000 | 18,326,000 | $67.44 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 681,803 | 33,147 | 31,438,000 | -18,586,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 648,656 | 94,392 | 50,024,000 | 3,338,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 554,264 | -17,650 | 46,686,000 | -85,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 571,914 | 433,546 | 46,771,000 | 38,861,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 138,368 | 0 | 7,910,000 | -1,326,000 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 138,368 | 12,306 | 9,236,000 | 2,750,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 126,062 | 0 | 6,486,000 | -876,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 126,062 | 62,555 | 7,362,000 | 4,712,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 63,507 | -21,898 | 2,650,000 | -1,861,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 85,405 | 0 | 4,511,000 | 933,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 85,405 | 85,405 | 3,578,000 | 3,578,000 | $41.89 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 60,405 | 60,405 | 2,452,000 | 2,452,000 | $40.59 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 60,405 | 60,405 | 3,921,000 | 3,921,000 | $64.91 |
| 09/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -10,000 | 0 | -458,000 | |
| 06/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 10,000 | 10,000 | 458,000 | 458,000 | $45.80 |
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