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TWO SIGMA INVESTMENTS, LP
> COLL
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 365,622 | 6,413 | 7,857,217,000 | -760,207,000 | $21,490.00 |
| 03/31/2023 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 359,209 | 245,663 | 8,617,424,000 | 5,983,157,000 | $23,990.00 |
| 12/31/2022 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 113,546 | 113,546 | 2,634,267,000 | 2,634,267,000 | $23,200.00 |
| 06/30/2022 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 0 | -28,734 | 0 | -585,000 | |
| 03/31/2022 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 28,734 | 28,734 | 585,000 | 585,000 | $20.36 |
| 09/30/2021 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 0 | -41,734 | 0 | -987,000 | |
| 06/30/2021 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 41,734 | -774 | 987,000 | -20,000 | $23.65 |
| 03/31/2021 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 42,508 | 42,508 | 1,007,000 | 1,007,000 | $23.69 |
| 09/30/2020 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 0 | -112,538 | 0 | -1,969,000 | |
| 06/30/2020 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 112,538 | -69,375 | 1,969,000 | -1,002,000 | $17.50 |
| 03/31/2020 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 181,913 | 118,977 | 2,971,000 | 1,676,000 | $16.33 |
| 12/31/2019 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 62,936 | 62,936 | 1,295,000 | 1,295,000 | $20.58 |
| 06/30/2019 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 0 | -69,072 | 0 | -1,046,000 | |
| 03/31/2019 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 69,072 | 69,072 | 1,046,000 | 1,046,000 | $15.14 |
| 12/31/2018 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 0 | -228,319 | 0 | -3,365,000 | |
| 09/30/2018 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 228,319 | 214,116 | 3,365,000 | 3,026,000 | $14.74 |
| 06/30/2018 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 14,203 | 3,916 | 339,000 | 76,000 | $23.87 |
| 03/31/2018 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 10,287 | -53,436 | 263,000 | -913,000 | $25.57 |
| 12/31/2017 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 63,723 | 63,723 | 1,176,000 | 1,176,000 | $18.45 |
| 03/31/2016 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 0 | -8,500 | 0 | -234,000 | |
| 12/31/2015 | COLLEGIUM PHARMACEUTICAL, INC | COLL | 8,500 | 8,500 | 234,000 | 234,000 | $27.53 |
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