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TWO SIGMA INVESTMENTS, LP
> RARE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Ultragenyx Pharmaceutical Inc. | RARE | 403,774 | -84,582 | 18,626,095,000 | -956,981,000 | $46,130.00 |
| 03/31/2023 | Ultragenyx Pharmaceutical Inc. | RARE | 488,356 | 46,420 | 19,583,076,000 | -891,819,000 | $40,100.00 |
| 12/31/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 441,936 | 385,436 | 20,474,895,000 | 20,471,524,000 | $46,330.00 |
| 06/30/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 56,500 | 17,600 | 3,371,000 | 546,000 | $59.66 |
| 03/31/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 38,900 | 38,900 | 2,825,000 | 2,825,000 | $72.62 |
| 12/31/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 0 | -25,900 | 0 | -2,336,000 | |
| 09/30/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 25,900 | -264,364 | 2,336,000 | -25,341,000 | $90.19 |
| 06/30/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 290,264 | 145,944 | 27,677,000 | 11,245,000 | $95.35 |
| 03/31/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 144,320 | 84,008 | 16,432,000 | 8,083,000 | $113.86 |
| 12/31/2020 | Ultragenyx Pharmaceutical Inc. | RARE | 60,312 | 54,595 | 8,349,000 | 7,879,000 | $138.43 |
| 09/30/2020 | Ultragenyx Pharmaceutical Inc. | RARE | 5,717 | -33,837 | 470,000 | -2,624,000 | $82.21 |
| 06/30/2020 | Ultragenyx Pharmaceutical Inc. | RARE | 39,554 | 39,554 | 3,094,000 | 3,094,000 | $78.22 |
| 12/31/2019 | Ultragenyx Pharmaceutical Inc. | RARE | 0 | -7,759 | 0 | -332,000 | |
| 09/30/2019 | Ultragenyx Pharmaceutical Inc. | RARE | 7,759 | 7,759 | 332,000 | 332,000 | $42.79 |
| 03/31/2016 | Ultragenyx Pharmaceutical Inc. | RARE | 0 | -145,341 | 0 | -14,881,000 | |
| 12/31/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 0 | -150,113 | 0 | -14,457,000 | |
| 09/30/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 150,113 | 4,772 | 14,457,000 | -424,000 | $96.31 |
| 06/30/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 145,341 | 145,341 | 14,881,000 | 14,881,000 | $102.39 |
| 03/31/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 12,821 | 12,821 | 796,000 | 796,000 | $62.09 |
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