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LOOMIS SAYLES & CO L P
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,275,310 | -96,336 | 1,152,614,000 | 90,310,000 | $351.91 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,371,646 | -786,744 | 1,062,304,000 | -141,717,000 | $315.07 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,158,390 | -299,346 | 1,204,021,000 | -52,124,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,457,736 | -1,931,287 | 1,256,145,000 | -411,198,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,389,023 | -246,230 | 1,667,343,000 | 210,241,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,635,253 | -370,739 | 1,457,102,000 | 186,285,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,005,992 | 4,955,119 | 1,270,817,000 | 857,299,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,050,873 | 2,049,877 | 413,518,000 | 413,304,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 996 | 810 | 214,000 | 170,000 | $214.86 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 186 | -440 | 44,000 | -126,000 | $236.56 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 626 | 159 | 170,000 | 34,000 | $271.57 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 467 | -41 | 136,000 | 15,000 | $291.22 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 508 | 26 | 121,000 | 15,000 | $238.19 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 482 | 482 | 106,000 | 106,000 | $219.92 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -3,036,552 | 0 | -287,501,000 | |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,036,552 | 3,036,552 | 287,501,000 | 287,501,000 | $94.68 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,459,880 | 3,459,880 | 244,683,000 | 244,683,000 | $70.72 |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,754,233 | 3,754,233 | 278,939,000 | 278,939,000 | $74.30 |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,754,233 | 3,754,233 | 284,646,000 | 284,646,000 | $75.82 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,983,319 | 362,683 | 318,148,000 | 119,085,000 | $79.87 |
| 03/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,620,636 | -12,000 | 199,063,000 | 46,710,000 | $54.98 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,632,636 | -281,322 | 152,353,000 | -66,633,000 | $41.94 |
| 09/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,913,958 | -33,352 | 218,986,000 | -1,748,000 | $55.95 |
| 06/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,947,310 | -34,807 | 220,734,000 | 57,427,000 | $55.92 |
| 03/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,982,117 | -494,870 | 163,307,000 | -69,451,000 | $41.01 |
| 12/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,021,300 | -455,687 | 133,547,000 | -99,211,000 | $33.21 |
| 06/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,476,987 | -304,866 | 232,758,000 | 3,564,000 | $51.99 |
| 03/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,781,853 | 697,694 | 229,194,000 | 86,126,000 | $47.93 |
| 12/31/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,084,159 | 0 | 143,068,000 | 1,879,000 | $35.03 |
| 09/30/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,084,159 | -38,319 | 141,189,000 | 5,559,000 | $34.57 |
| 06/30/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,122,478 | -147,688 | 135,630,000 | -38,892,000 | $32.90 |
| 03/31/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,270,166 | -1,661 | 174,522,000 | -8,526,000 | $40.87 |
| 12/31/2009 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,271,827 | 20,473 | 183,048,000 | 21,922,000 | $42.85 |
| 09/30/2009 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,251,354 | -141,752 | 161,126,000 | 4,556,000 | $37.90 |
| 06/30/2009 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,393,106 | 2,072,850 | 156,570,000 | 89,909,000 | $35.64 |
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