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TWO SIGMA ADVISERS, LP
> ALPN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 86,375 | 45,400 | 887,935,000 | 571,608,000 | $10,280.00 |
| 03/31/2023 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 40,975 | -24,200 | 316,327,000 | -162,709,000 | $7,720.00 |
| 12/31/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 65,175 | -3,300 | 479,036,000 | 478,543,000 | $7,350.00 |
| 09/30/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 68,475 | -33,100 | 493,000 | -371,000 | $7.20 |
| 06/30/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 101,575 | -12,600 | 864,000 | -160,000 | $8.51 |
| 03/31/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 114,175 | 6,400 | 1,024,000 | -469,000 | $8.97 |
| 12/31/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 107,775 | 66,100 | 1,493,000 | 1,048,000 | $13.85 |
| 09/30/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 41,675 | -27,500 | 445,000 | -178,000 | $10.68 |
| 06/30/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 69,175 | -56,800 | 623,000 | -712,000 | $9.01 |
| 03/31/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 125,975 | 23,200 | 1,335,000 | 40,000 | $10.60 |
| 12/31/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 102,775 | 29,300 | 1,295,000 | 649,000 | $12.60 |
| 09/30/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 73,475 | 73,475 | 646,000 | 646,000 | $8.79 |
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