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ORBIMED ADVISORS LLC
> QURE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | uniQure N.V. | QURE | 2,064,455 | 0 | 23,658,654,000 | -17,919,470,000 | $11,460.00 |
| 03/31/2023 | uniQure N.V. | QURE | 2,064,455 | 316,900 | 41,578,124,000 | 1,961,052,000 | $20,140.00 |
| 12/31/2022 | uniQure N.V. | QURE | 1,747,555 | 150,555 | 39,617,072,000 | 39,587,112,000 | $22,670.00 |
| 09/30/2022 | uniQure N.V. | QURE | 1,597,000 | 722,151 | 29,960,000 | 13,653,000 | $18.76 |
| 06/30/2022 | uniQure N.V. | QURE | 874,849 | -44,400 | 16,307,000 | -304,000 | $18.64 |
| 03/31/2022 | uniQure N.V. | QURE | 919,249 | 333,675 | 16,611,000 | 4,466,000 | $18.07 |
| 12/31/2021 | uniQure N.V. | QURE | 585,574 | 114,400 | 12,145,000 | -2,367,000 | $20.74 |
| 06/30/2021 | uniQure N.V. | QURE | 471,174 | -497,905 | 14,512,000 | -18,136,000 | $30.80 |
| 03/31/2021 | uniQure N.V. | QURE | 969,079 | 0 | 32,648,000 | -2,365,000 | $33.69 |
| 12/31/2020 | uniQure N.V. | QURE | 969,079 | 0 | 35,013,000 | -678,000 | $36.13 |
| 09/30/2020 | uniQure N.V. | QURE | 969,079 | 0 | 35,691,000 | -7,976,000 | $36.83 |
| 06/30/2020 | uniQure N.V. | QURE | 969,079 | -14,900 | 43,667,000 | -3,023,000 | $45.06 |
| 03/31/2020 | uniQure N.V. | QURE | 983,979 | -97,786 | 46,690,000 | -30,829,000 | $47.45 |
| 12/31/2019 | uniQure N.V. | QURE | 1,081,765 | 242,165 | 77,519,000 | 44,472,000 | $71.66 |
| 09/30/2019 | uniQure N.V. | QURE | 839,600 | -58,200 | 33,047,000 | -37,116,000 | $39.36 |
| 06/30/2019 | uniQure N.V. | QURE | 897,800 | 897,800 | 70,163,000 | 70,163,000 | $78.15 |
| 12/31/2016 | uniQure N.V. | QURE | 0 | -489,000 | 0 | -3,741,000 | |
| 09/30/2016 | uniQure N.V. | QURE | 489,000 | 293,600 | 3,741,000 | 2,301,000 | $7.65 |
| 06/30/2016 | uniQure N.V. | QURE | 195,400 | 195,400 | 1,440,000 | 1,440,000 | $7.37 |
| 03/31/2016 | uniQure N.V. | QURE | 184,800 | 184,800 | 2,195,000 | 2,195,000 | $11.88 |
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