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ORBIMED ADVISORS LLC
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| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | SYNLOGIC, INC. | SYBX | 6,029,995 | 0 | 2,592,898,000 | -1,218,059,000 | $430.00 |
| 03/31/2023 | SYNLOGIC, INC. | SYBX | 6,029,995 | 0 | 3,810,957,000 | -771,839,000 | $632.00 |
| 12/31/2022 | SYNLOGIC, INC. | SYBX | 6,029,995 | 0 | 4,582,796,000 | 4,577,068,000 | $760.00 |
| 09/30/2022 | SYNLOGIC, INC. | SYBX | 6,029,995 | 0 | 5,728,000 | -1,206,000 | $0.95 |
| 06/30/2022 | SYNLOGIC, INC. | SYBX | 6,029,995 | 0 | 6,934,000 | -7,538,000 | $1.15 |
| 03/31/2022 | SYNLOGIC, INC. | SYBX | 6,029,995 | 0 | 14,472,000 | -121,000 | $2.40 |
| 12/31/2021 | SYNLOGIC, INC. | SYBX | 6,029,995 | 2,333,333 | 14,593,000 | 213,000 | $2.42 |
| 06/30/2021 | SYNLOGIC, INC. | SYBX | 3,696,662 | 1,666,666 | 14,380,000 | 7,113,000 | $3.89 |
| 03/31/2021 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 7,267,000 | 2,882,000 | $3.58 |
| 03/25/2021 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 7,977,884 | 3,592,884 | $3.93 |
| 12/31/2020 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 4,385,000 | 284,000 | $2.16 |
| 09/30/2020 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 4,101,000 | -20,000 | $2.02 |
| 06/30/2020 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 4,121,000 | 629,000 | $2.03 |
| 03/31/2020 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 3,492,000 | -1,745,000 | $1.72 |
| 12/31/2019 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 5,237,000 | 588,000 | $2.58 |
| 09/30/2019 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 4,649,000 | -13,824,000 | $2.29 |
| 06/30/2019 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 18,473,000 | 3,065,000 | $9.10 |
| 06/11/2019 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 12,728,075 | -2,679,925 | $6.27 |
| 03/31/2019 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 15,408,000 | 1,178,000 | $7.59 |
| 12/31/2018 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 14,230,000 | -14,616,000 | $7.01 |
| 09/30/2018 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 28,846,000 | 8,891,000 | $14.21 |
| 06/30/2018 | SYNLOGIC, INC. | SYBX | 2,029,996 | 0 | 19,955,000 | 914,000 | $9.83 |
| 04/10/2018 | SYNLOGIC, INC. | SYBX | 2,029,996 | 715,000 | 21,477,358 | 8,722,358 | $10.58 |
| 03/31/2018 | SYNLOGIC, INC. | SYBX | 2,029,996 | 715,000 | 19,041,000 | 6,286,000 | $9.38 |
| 01/24/2018 | SYNLOGIC, INC. | SYBX | 2,029,996 | 715,000 | 19,690,961 | -5,314,039 | $9.70 |
| 12/31/2017 | SYNLOGIC, INC. | SYBX | 1,314,996 | 0 | 12,755,000 | -12,250,000 | $9.70 |
| 09/30/2017 | SYNLOGIC, INC. | SYBX | 1,314,996 | 0 | 25,005,000 | 9,132,998 | $19.02 |
| 08/28/2017 | SYNLOGIC, INC. | SYBX | 1,314,996 | 1,314,996 | 15,872,002 | 15,872,002 | $12.07 |
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