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Opaleye Management Inc.
> RYTM
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 735,000 | -75,000 | 12,120,150,000 | 12,100,305,000 | $16,490.00 |
| 09/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 810,000 | 448,000 | 19,845,000 | 18,343,000 | $24.50 |
| 06/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 362,000 | 362,000 | 1,502,000 | 1,502,000 | $4.15 |
| 03/31/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -115,000 | 0 | -3,419,000 | |
| 12/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 115,000 | 115,000 | 3,419,000 | 3,419,000 | $29.73 |
| 03/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -110,500 | 0 | -2,537,000 | |
| 12/31/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 110,500 | 110,500 | 2,537,000 | 2,537,000 | $22.96 |
| 03/31/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -38,300 | 0 | -1,113,000 | |
| 12/31/2017 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 38,300 | 38,300 | 1,113,000 | 1,113,000 | $29.06 |
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