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STATE STREET CORP
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,581,469 | -597,599 | 73,107,202,000 | -16,161,027,000 | $28,320.00 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 3,179,068 | 544,296 | 89,268,229,000 | 89,193,718,000 | $28,080.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,634,772 | -766,447 | 74,511,000 | -894,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 3,401,219 | 214,706 | 75,405,000 | -17,354,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 3,186,513 | 193,631 | 92,759,000 | -5,617,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,992,882 | 599,992 | 98,376,000 | -12,056,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,392,890 | 422,831 | 110,432,000 | 1,862,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,970,059 | 237,469 | 108,570,000 | 19,099,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,732,590 | -889,691 | 89,471,000 | -24,152,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,622,281 | 555,259 | 113,623,000 | 41,277,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,067,022 | 172,394 | 72,346,000 | -28,979,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,894,628 | -14,681 | 101,325,000 | 33,583,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,909,309 | 24,523 | 67,742,000 | -22,257,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,884,786 | 33,449 | 89,999,000 | 30,016,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,851,337 | 104,222 | 59,983,000 | -27,163,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,747,115 | 157,544 | 87,146,000 | -20,055,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,589,571 | -56,357 | 107,201,000 | 31,307,000 | $67.44 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,645,928 | 83,947 | 75,894,000 | -44,566,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,561,981 | 213,465 | 120,460,000 | 6,873,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,348,516 | 5,877 | 113,587,000 | 36,837,000 | $84.23 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,342,639 | 86,918 | 76,750,000 | -7,066,000 | $57.16 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,255,721 | -47,245 | 83,816,000 | 16,780,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,302,966 | 97,220 | 67,036,000 | -3,381,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,205,746 | -34,839 | 70,417,000 | 18,645,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,240,585 | 150,244 | 51,772,000 | -5,822,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,090,341 | 191,155 | 57,594,000 | 19,922,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 899,186 | -204,476 | 37,672,000 | -7,131,000 | $41.90 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,103,662 | 521,315 | 44,803,000 | 3,698,000 | $40.59 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 903,194 | 320,847 | 58,631,000 | 17,526,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 582,347 | 108,466 | 41,105,000 | -11,558,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 473,881 | 27,118 | 52,663,000 | 10,532,000 | $111.13 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 446,763 | 73,380 | 42,131,000 | 301,000 | $94.30 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 373,383 | -170,801 | 41,830,000 | 8,445,000 | $112.03 |
| 09/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 544,184 | 370,286 | 33,385,000 | 25,414,000 | $61.35 |
| 06/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 173,898 | 85,117 | 7,971,000 | 4,495,000 | $45.84 |
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